Briefly reviews the literature on infertility and its emotional, physical, existential, and relational effects on individuals, couples, and families. Life crisis and biopsychosocial theories are discussed as they apply to persons struggling with infertility issues. In addition, stage models derived from a biopsychosocial perspective are presented. Treatment suggestions are posited for the mental health practitioner working with individuals and/or couples. (Contains 64 references.) (GCP)