Optimal design of multisite randomized trials leverages sampling costs to optimize sampling ratios and ultimately identify more efficient and powerful designs. Past implementations of the optimal design framework have assumed that costs of sampling units are equal across treatment conditions. In this study, we developed a more flexible optimal…

Optimal sampling frameworks attempt to identify the most efficient sampling plans to achieve an adequate statistical power. Although such calculations are theoretical in nature, they are critical to the judicious and wise use of funding because they serve as important starting points that guide practical discussions around sampling tradeoffs and…

When well-implemented, mediation analyses play a critical role in probing theories of action because their results help lay the ground work for the critical development of a treatment and the iterative advancement of theories that are foundational to a discipline. Despite strong interest in designs that incorporate mediation, few studies have…

Conventional optimal design frameworks consider a narrow range of sampling cost structures that thereby constrict their capacity to identify the most powerful and efficient designs. We relax several constraints of previous optimal design frameworks by allowing for variable sampling costs in cluster-randomized trials. The proposed framework…

School-based improvement programs represent a core strategy in improving education because they can leverage pre-existing social and organizational structures to promote coordinated and comprehensive change across multiple facets of schooling. School-based programs are generally designed to be implemented by intact schools/districts, frequently…