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An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder
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Lewis, Alan S.; van Schalkwyk, Gerrit Ian; Lopez, Mayra Ortiz; Volkmar, Fred R.; Picciotto, Marina R.; Sukhodolsky, Denis G. – Journal of Autism and Developmental Disorders, 2018
Nicotinic acetylcholine receptors (nAChRs), particularly the a7 nAChR, are implicated in the pathophysiology of both autism spectrum disorder (ASD) and aggressive behavior. We explored the feasibility, tolerability, and preliminary efficacy of targeting nAChRs using transdermal nicotine to reduce aggressive symptoms in adults with ASD. Eight…
Descriptors: Aggression, Adults, Stimulants, Pervasive Developmental Disorders
Do You Really Lose When You Snooze? Sleep Correlates of Externalizing and Attention Problems among Pediatric Patients with ADHD, ASD, and Comorbid Diagnosis
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Ng, Rowena; Heinrich, Kimberley; Hodges, Elise – Journal of Mental Health Research in Intellectual Disabilities, 2020
Introduction: The primary aim of this retrospective study was to assess differential associations between sleep disturbances with externalizing/internalizing problems, ADHD profiles (inattention, hyperactivity/impulsivity), and social impairment among children with ADHD, autism spectrum disorder (ASD), and comorbid diagnoses (ASD+ADHD). Methods:…
Descriptors: Sleep, Correlation, Comorbidity, Attention Deficit Hyperactivity Disorder