Convergent data suggest dissociated roles for the lateral (LA) and basolateral (BLA) amygdaloid nuclei in fear conditioning, depending on whether a discrete conditioned stimulus (CS)-unconditional stimulus (US) or context-US association is considered. Here, we show that pretraining inactivation of the BLA selectively impaired conditioning to…

This study evaluated eye-blink conditioning in 11 persons with autism (ages 11 to 22). Compared to matched controls, persons with autism learned the task faster but performed short-latency, high-amplitude conditioned responses. Results suggest this population has the ability to rapidly associate paired stimuli but may have impairments in…

Like many forms of Pavlovian conditioning, eyelid conditioning displays robust extinction. We used a computer simulation of the cerebellum as a tool to consider the widely accepted view that extinction involves new, inhibitory learning rather than unlearning of acquisition. Previously, this simulation suggested basic mechanistic features of…