In this case study, we describe our proposed solution to help students 'see' and understand sub-cellular structures in a three-dimensional virtual learning environment and the challenges of implementing this innovation in Singapore schools. The teaching of molecular biology in Singapore suffers from student disengagement and lack of suitable resources to help students master this area of their curriculum. Traditionally, diagrams and models accommodate visual-spatial learners in science classrooms. However, these are insufficient to represent the cellular and molecular dynamics described in modern biology. This experimental study and intervention, undertaken between 2011 and 2012, leverages on novel computer-based virtual reality technologies. Pretest and posttest Rasch measures using data from 249 students from seven schools were collected and analyzed. The purposive sampling was designed, so the results would be more applicable to the wider student population in Singapore but was itself a challenge, particularly in the Asian context. We hope that our experiences of education research in Singapore serves as a useful guide to anyone considering similar work in the Asian context. [This content is provided in the format of an e-book.]