This study examines state- and county-level data on population, age, race and ethnicity, housing occupancy and housing tenure, education, labor force, employment and unemployment, income and poverty, health insurance coverage, disability status, migration patterns, and veteran status from the 2010-2014 American Community Survey (ACS) for the 13 Appalachian states. Information is summarized for five Appalachian subregions and five metro designations. The study includes ACS data topics that were in the 2010 decennial census, as well as others that are no longer available in the census, to provide a comparable time series of data for all counties in Appalachia. For the first time, this report compares two non-overlapping five-year periods and allows for the study of trends in the data.