The "2021 Annual Report on People with Disabilities in America" is a companion volume to the "2021 Annual Disability Statistics Compendium" (ED620434) and "Supplement" (ED620434). Indicators were in the following areas of interest: employment, educational attainment, health and health care, financial status and security, leisure recreation, personal relationships, and crime/safety. Due to the COVID-19 Pandemic, data collection activities were interrupted. In 2020, for each of these indicators, a "statistically significant" gap was detected, meaning there is a certainty that each of these gaps is greater than zero. Unfortunately, due to the data collection issues, there is no way to determine whether the gaps between people with and without disabilities increased. It is unknown whether 2021 estimates will be comparable to 2020 estimates or 2019 estimates. [For the 2020 Annual Report, see ED613092.]