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Direct linkJinma Ren; Jia Ma; Joseph C. Cappelleri – Research Synthesis Methods, 2024
A random-effects model is often applied in meta-analysis when considerable heterogeneity among studies is observed due to the differences in patient characteristics, timeframe, treatment regimens, and other study characteristics. Since 2014, the journals "Research Synthesis Methods" and the "Annals of Internal Medicine" have…
Descriptors: Meta Analysis, Effect Size, Oncology, Patients
Konstantina Chalkou; Tasnim Hamza; Pascal Benkert; Jens Kuhle; Chiara Zecca; Gabrielle Simoneau; Fabio Pellegrini; Andrea Manca; Matthias Egger; Georgia Salanti – Research Synthesis Methods, 2024
Some patients benefit from a treatment while others may do so less or do not benefit at all. We have previously developed a two-stage network meta-regression prediction model that synthesized randomized trials and evaluates how treatment effects vary across patient characteristics. In this article, we extended this model to combine different…
Descriptors: Medical Research, Outcomes of Treatment, Risk, Randomized Controlled Trials
