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Murphy Angelo; Yash Bhargava; Scott Takeo Aoki – Biochemistry and Molecular Biology Education, 2024
The complexity of RNA cannot be fully expressed with the canonical A, C, G, and U alphabet. To date, over 170 distinct chemical modifications to RNA have been discovered in living systems. RNA modifications can profoundly impact the cellular outcomes of messenger RNAs (mRNAs), transfer and ribosomal RNAs, and noncoding RNAs. Additionally, aberrant…
Descriptors: Genetics, Biochemistry, Molecular Biology, College Science
Hannah K. Parker; Beth Zizzamia; Julie A. Pollock – Journal of Chemical Education, 2025
In a typical undergraduate biochemistry course, two main educational objectives include (1) understanding and applying how genetic mutations can influence protein structure and function, and (2) examining metabolic pathways of biomolecules to study cellular storage and fuel. Many times, these topics can seem disparate to students; therefore, we…
Descriptors: Undergraduate Students, College Science, Science Instruction, Biochemistry
Kylie Light; Jordan Brooks; Yun-Seok Choi – Journal of Chemical Education, 2023
Sanger sequencing, also known as dideoxy sequencing, is a widely used method for DNA sequencing, particularly for cloned plasmids and clinical samples. This technique requires a combination of essential biochemistry skills, such as a chain-termination reaction, gel electrophoresis, and fluorescence detection. Unfortunately, there is a lack of…
Descriptors: Genetics, Biochemistry, Science Instruction, Science Activities
Jiro Kondo; Shota Nakamura – Journal of Chemical Education, 2023
The use of molecular models in chemistry and biochemistry classes is very effective in helping students understand covalent bonds and the chemical structure of molecules. However, conventional molecular models cannot represent intermolecular interactions such as hydrogen bonds and electrostatic interactions. Herein, we describe 3D printed…
Descriptors: Chemistry, Molecular Structure, Scientific Concepts, Biochemistry
Anithasri, Anbalagan – Biochemistry and Molecular Biology Education, 2020
Hormones are the major signaling molecules that have a complex signaling cascade involving intracellular and intranuclear receptors, coreceptors, and signal transduction pathways. The molecular mechanism of hormonal action is written in a poetic verse to kindle the interest of students and to augment their affinity toward the onerous yet awesome…
Descriptors: Genetics, Biochemistry, Molecular Structure, Cytology
Goodsell, David S.; Zardecki, Christine; Berman, Helen M.; Burley, Stephen K. – Biochemistry and Molecular Biology Education, 2020
For 20 years, Molecule of the Month articles have highlighted the functional stories of 3D structures found in the Protein Data Bank (PDB). The PDB is the primary archive of atomic structures of biological molecules, currently providing open access to more than 150,000 structures studied by researchers around the world. The wealth of knowledge…
Descriptors: Biochemistry, Molecular Structure, Archives, Genetics
Erasmus, Daniel J. – Biochemistry and Molecular Biology Education, 2021
Education in biochemistry teaching laboratories focus primarily on applying biochemical techniques to understanding human disease, biochemistry, and biotechnology. With anthropogenic climate change, there is a renewed interest in quantifying biodiversity, especially with the use of molecular-based approaches such as DNA barcoding. This 3-week…
Descriptors: Biochemistry, College Science, Undergraduate Students, Science Laboratories
Sousa, Cristina – American Biology Teacher, 2021
The origin of life is one of the most interesting and challenging questions in biology. This article discusses relevant contemporary theories and hypotheses about the origin of life, recent scientific evidence supporting them, and the main contributions of several scientists of different nationalities and specialties in different disciplines. Also…
Descriptors: Biology, Science Instruction, Cytology, Evolution
Keira D. Naff; Jeri L. Tyler; Dima H. Hamza; Jonathan D. White – Journal of Chemical Education, 2023
Structure--activity relationships are foundational concepts in biochemistry and drug design. Despite their importance, it can be difficult to create and execute laboratory activities that allow students to directly observe the interactions between small-molecule drugs and their biomolecular targets. Here, we report an activity that investigates…
Descriptors: Genetics, Undergraduate Students, Undergraduate Study, College Science
Andrew Phillips; Anusha Srinivas; Ilina Prentoska; Margaret O'Dea; Matthew Kustrup; Sarah Hurley; Savannah Bruno; Vy Nguyen; Pin-Kuang Lai – Biochemistry and Molecular Biology Education, 2024
Teaching chemistry and biology students about biologics design remains challenging despite its increasing importance in pharmaceutical development. Monoclonal antibodies, commonly called mAbs, are the most popular biologics. They have been developed into drugs to treat various diseases in the past decades. Multiple challenges exist for designing…
Descriptors: Teaching Methods, Biochemistry, Science Instruction, Computer Software
Mahaffey, Angela L. – Biochemistry and Molecular Biology Education, 2020
DNA analysis is a common diagnostic tool in healthcare: ranging from microbial typing (e.g. DNA strands of viral, bacterial and even fungal pathogens), oncological screen (e.g. Breast cancer detection via DNA analysis of any BRCA gene mutations), genetic amniocentesis test (a medical technique used in determining chromosomal conditions such as…
Descriptors: Genetics, Science Instruction, Clinical Diagnosis, Genetic Disorders
Latisha R. Jefferies; Andrea N. Giordano; Barry W. Hicks – Journal of Chemical Education, 2022
Although biochemistry is fascinating to undergraduates regardless of their major, the complexity involved requires a great deal of effort and leads many to perceive it to be an intense, facts-based course limiting personal creativity. This activity takes the fundamental knowledge associated with inducible promoters and combines it with the…
Descriptors: Science Education, Biochemistry, Undergraduate Study, Art Education
Kats, Ilona R.; Klann, Eric – Learning & Memory, 2019
Formation of eukaryotic initiation factor 4F (eIF4F) is widely considered to be the rate-limiting step in cap-dependent translation initiation. Components of eIF4F are often up-regulated in various cancers, and much work has been done to elucidate the role of each of the translation initiation factors in cancer cell growth and survival. In fact,…
Descriptors: Cancer, Brain, Biochemistry, Cytology
Mowrer, Emily R.; Potratz, Jeffrey P. – Journal of Chemical Education, 2020
Categorizing the various levels of protein and nucleic acid structures is a relatively straightforward concept students understand quickly when shown representative structural images. However, keeping in mind the idea of primary, secondary, and tertiary structure proves more difficult when students are in the laboratory setting simply looking at a…
Descriptors: Genetics, Teaching Methods, Science Education, Laboratory Experiments
Emrani, Jahangir; Ahmed, Maryam; Newman, Robert H.; Thomas, Misty D.; Mowa, Chishimba Nathan; Teleha, John – Journal of Chemical Education, 2020
Genome editing has widespread influence in many fields, including medicine, biotechnology, and agriculture. Despite their origins in chemistry laboratories, these techniques are currently under utilized in chemistry curricula. Introducing future generations of chemists to these emerging technologies is essential in chemistry classrooms. The…
Descriptors: College Science, Technological Advancement, Genetics, Ethics