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Nannas, Natalie J. – Bioscene: Journal of College Biology Teaching, 2021
CRISPR-Cas9 is revolutionizing how we conduct scientific research, treat disease, and develop new crops. The widespread impact of this genome-editing technology makes it critical for undergraduate students to understand and engage with this new tool. In this article, we describe a multi-week lab module that teaches undergraduates how to design…
Descriptors: Genetics, Science Instruction, Undergraduate Students, Scientific Research
Schafer, Adam G.; Yezierski, Ellen J.; Hartley, C. Scott – Journal of Chemical Education, 2019
A laboratory experiment was developed that connects the interpretation of computer-generated models to the self-assembly of macrocycles. Students compare the reactions of terephthalaldehyde and isophthalaldehyde by reacting each with (R,R)-(-)-1,2-diaminocyclohexane. These isomeric systems serve as the foundation for a discussion about the impact…
Descriptors: Undergraduate Students, Thermodynamics, Laboratory Experiments, Comparative Analysis
Sun, Ji-Zheng; Tang, Yu-Jing; Sa, Rong-Bo; Gao, Yan-Xia – Journal of Chemical Education, 2019
A bioinformatics laboratory experiment was designed to help undergraduate students learn RNA structure and function in biochemistry courses. In this laboratory experiment, students used 5S rRNAs as material to predict secondary structure and visualize three-dimensional (3D) structure. Students first downloaded molecular information from the 5S…
Descriptors: Science Laboratories, Laboratory Experiments, Science Experiments, Information Science
Paul, Noel M.; Yoder, Ryan J.; Callam, Christopher S. – Journal of Chemical Education, 2019
Fluency in both the construction and interpretation of molecular structures is a critical learning objective in the second-year organic chemistry curriculum. With the introduction of PerkinElmer's ChemDraw structure drawing tool into undergraduate laboratory courses, students are challenged to develop fundamental molecular drawing skills using…
Descriptors: Organic Chemistry, Science Instruction, Computer Assisted Instruction, Computer Software
Kholod, Yana; Hoag, Erin; Muratore, Katlynn; Kosenkov, Dmytro – Journal of Chemical Education, 2018
The reported project-based laboratory unit introduces upper-division undergraduate students to the basics of computer-aided drug discovery as a part of a computational chemistry laboratory course. The students learn to perform model binding of organic molecules (ligands) to the DNA minor groove with computer-aided drug discovery (CADD) tools. The…
Descriptors: Science Laboratories, College Science, Undergraduate Study, Chemistry
Fasoula, S.; Nikitas, P.; Pappa-Louisi, A. – Journal of Chemical Education, 2017
A series of Microsoft Excel spreadsheets were developed to simulate the process of separation optimization under isocratic and simple gradient conditions. The optimization procedure is performed in a stepwise fashion using simple macros for an automatic application of this approach. The proposed optimization approach involves modeling of the peak…
Descriptors: Simulation, Spreadsheets, Chemistry, Science Laboratories
Tavares, Maurício T.; Primi, Marina C.; Silva, Nuno A. T. F.; Carvalho, Camila F.; Cunha, Micael R.; Parise-Filho, Roberto – Journal of Chemical Education, 2017
Teaching the molecular aspects of drug-target interactions and selectivity is not always an easy task. In this context, the use of alternative and engaging approaches could help pharmacy and chemistry students better understand this important topic of medicinal chemistry. Herein a 4 h practical exercise that uses freely available software as a…
Descriptors: Science Instruction, Teaching Methods, Pharmacology, College Science
Haworth, Naomi L.; Martin, Lisandra L. – Journal of Chemical Education, 2018
A series of computer-based laboratory experiments have been developed to aid undergraduate students in appreciating the three-dimensional nature of chemistry and biochemistry. Both lower- and upper-division experiments have been developed. Students are introduced to the use of ChemDraw for the production of professional-quality molecular…
Descriptors: Science Instruction, College Science, Undergraduate Study, Computer Assisted Instruction
Best, Katherine T.; Li, Diana; Helms, Eric D. – Journal of Chemical Education, 2017
The electrophilic addition of a hydrohalic acid (HX) to an alkene is often one of the first reactions learned in second-year undergraduate organic chemistry classes. During the ensuing discussion of the mechanism, it is shown that this reaction follows Markovnikov's rule, which states that the hydrogen atom will attach to the carbon with fewer…
Descriptors: Organic Chemistry, Undergraduate Study, Science Instruction, College Science
Guerin, Abby C.; Riley, Kristi; Rupnik, Kresimir; Kuroda, Daniel G. – Journal of Chemical Education, 2016
Hydrogen bonds are very important chemical structures that are responsible for many unique and important properties of solvents, such as the solvation power of water. These distinctive features are directly related to the stabilization energy conferred by hydrogen bonds to the solvent. Thus, the characterization of hydrogen bond energetics has…
Descriptors: Chemistry, Laboratory Experiments, Science Instruction, Energy
Brom, Joseph M. – Journal of Chemical Education, 2017
The concept of wave-particle duality in quantum theory is difficult to grasp because it attributes particle-like properties to classical waves and wave-like properties to classical particles. There seems to be an inconsistency involved with the notion that particle-like or wave-like attributes depend on how you look at an entity. The concept comes…
Descriptors: Chemistry, Science Instruction, Measurement Techniques, Scientific Concepts
Snider, Barry B. – Journal of Chemical Education, 2015
In this experiment, students carry out a modern organocatalytic reaction using IMes·HCl and NaOH to catalyze the formation of 1,3,4-triphenylcyclopentene from cinnamaldehyde and chalcone in water. Deprotonation of IMes·HCl with NaOH forms the "N"-heterocyclic carbene IMes that reacts with cinnamaldehyde to form a homoenolate equivalent…
Descriptors: Science Instruction, Science Experiments, Scientific Concepts, College Science
Petrovic, Dus?an; Zlatovic´, Mario – Journal of Chemical Education, 2015
A homology modeling laboratory experiment has been developed for an introductory molecular modeling course for upper-division undergraduate chemistry students. With this experiment, students gain practical experience in homology model preparation and assessment as well as in protein visualization using the educational version of PyMOL…
Descriptors: Science Experiments, Laboratory Experiments, Undergraduate Study, College Science
Joseph M. Hayes – Journal of Chemical Education, 2014
A 3D model visualization and basic molecular modeling laboratory suitable for first-year undergraduates studying introductory medicinal chemistry is presented. The 2 h practical is embedded within a series of lectures on drug design, target-drug interactions, enzymes, receptors, nucleic acids, and basic pharmacokinetics. Serving as a teaching aid…
Descriptors: Visualization, Models, Visual Aids, Undergraduate Students
Martini, Sheridan R.; Hartzell, Cynthia J. – Journal of Chemical Education, 2015
Computational chemistry is commonly addressed in the quantum mechanics course of undergraduate physical chemistry curricula. Since quantum mechanics traditionally follows the thermodynamics course, there is a lack of curricula relating computational chemistry to thermodynamics. A method integrating molecular modeling software into a semester long…
Descriptors: Science Instruction, Chemistry, Quantum Mechanics, College Science