Experiments that explore quantum principles while utilizing and reinforcing previous synthesis skills are excellent for engaging students and promoting the interconnected nature of chemistry. This experiment utilizes sophomore-level organic synthesis techniques to have students produce their own "meso" substituted porphyrins. The UV-vis…

The addition of research-focused experiences to undergraduate chemistry laboratory courses has been shown to bolster student learning, enhance student retention in STEM, and improve student self-identity as scientists. In the area of synthetic organic chemistry, the preparation of libraries of compounds with novel optical and electronic properties…

When structure-property relationships are discussed in inorganic chemistry and materials science, the common perception is that materials with the same composition and atomic arrangement have the same properties. In this laboratory experiment, we show that "processing"--the exact conditions under which materials are made--can in fact…

A comprehensive chemistry laboratory experiment, including the synthesis of Pt/Al[subscript 2]O[subscript 3] catalysts at different conditions, structure characterization, and the real-world application exploration, has been designed for upper-division undergraduate and graduate students as an expansion and improvement of the professional…

A one-pot multicomponent synthesis of unsymmetrical indole-substituted methane derivative based on two consecutive reactions of p-methylbenzaldehyde with N-methylindole and 5,5-dimethyl-1,3-cyclohexanedione is described as an experiment that was carried out by second-year undergraduate chemistry students individually in a laboratory classroom. The…

A multistep synthesis of a metal-free organic dye-sensitizer for solar cells was developed as a multifaceted research project for upper-division undergraduate students with a goal of introducing students to the application of organic synthesis in material science, and renewable energy research. The characterization of the dye is done by thin-layer…

The dangers of organic dye pollutants and environmental pollution improvement through photocatalytic degradation are important courses in applied chemistry programs in universities. Zinc oxide (ZnO)-based nanomaterials are potent catalytic agents against organic dyes, but few experiments are available for students to understand their role and…

An operationally simple, reliable synthesis of ethynylated acenes suitable for an upper-division undergraduate organic chemistry laboratory course has been developed. This experiment requires students to synthesize two acene derivatives and can be completed in 6-8 laboratory sessions (3 h each); a shorter experiment could be realized in the…

A multistep synthesis of quinolone antibiotic analogues was developed as a laboratory experiment for intermediate/advanced undergraduate students. Students can synthesize a range of "des"fluoroenoxacin analogues via a five-step sequence. The experiment includes a range of key practical laboratory techniques including thin-layer…

A research-style laboratory experiment composed of the synthesis of MOF-74 materials, related structural characterization, and the cutting-edge application of electrocatalytic oxygen evolution reaction (OER) has been designed toward advanced undergraduates at East China University of Technology (ECUT). The desired monometallic MOF-74 (Ni-MOF-74…

Three different experiments that allow the synthesis of the drug paracetamol are described; such experiments were designed for their implementation in undergraduate organic chemistry courses, considering the medical and economic importance of paracetamol. The experience wants to show the students some "real world" applications of organic…

One dimensional (1-D)[superscript 1] H and [superscript 13]C NMR experiments are common tools used in undergraduate organic laboratories to characterize synthesized molecules. However, 1-D NMR spectra cannot always provide unambiguous structure determination. In research laboratories, advanced NMR spectroscopy methods are employed for structural…

A procedure for the solution polymerization of styrene using di-"tert"-butyl peroxide (DTBP) as the initiator is described. The use of DTBP allows for end-group analysis by [superscript 1]H NMR spectroscopy and calculation of the number-average molecular weight of the polymer. This experiment was designed as a laboratory introduction to…

Two experiments are described which lead to the preparation of dimethyl fumarate, a compound currently used in the treatment of multiple sclerosis. Preparation of a compound with "real-world" applications is believed to increase student interest in the experiment. One experiment involves the isomerization of dimethyl maleate to the…

In an effort to repurpose expired guaifenesin tablets, experiments devised for practical instruction are reported for the preparation and isolation of the guaifenesin acetonide using a microscale kit. The laboratory experiment successfully utilizes a waste chemical in lieu of a fine chemical to illustrate the principles behind protecting groups in…