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Learning & Memory2
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Amano, Hisayuki1
Darvas, Martin1
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Aversive Olfactory Learning and Associative Long-Term Memory in "Caenorhabditis elegans"
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Amano, Hisayuki; Maruyama, Ichiro N. – Learning & Memory, 2011
The nematode "Caenorhabditis elegans" ("C. elegans") adult hermaphrodite has 302 invariant neurons and is suited for cellular and molecular studies on complex behaviors including learning and memory. Here, we have developed protocols for classical conditioning of worms with 1-propanol, as a conditioned stimulus (CS), and hydrochloride (HCl) (pH…
Descriptors: Stimuli, Classical Conditioning, Long Term Memory, Olfactory Perception
Requirement of Dopamine Signaling in the Amygdala and Striatum for Learning and Maintenance of a Conditioned Avoidance Response
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Darvas, Martin; Fadok, Jonathan P.; Palmiter, Richard D. – Learning & Memory, 2011
Two-way active avoidance (2WAA) involves learning Pavlovian (association of a sound cue with a foot shock) and instrumental (shock avoidance) contingencies. To identify regions where dopamine (DA) is involved in mediating 2WAA, we restored DA signaling in specific brain areas of dopamine-deficient (DD) mice by local reactivation of conditionally…
Descriptors: Animals, Classical Conditioning, Genetics, Biochemistry