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Direct linkJonkman, Sietse; Everitt, Barry J. – Learning & Memory, 2011
The evidence for a role of the striatum in the acquisition of uncued instrumental responding is ambiguous. It has been shown that post-session infusions of anisomycin into the core of the nucleus accumbens (NAcc) impaired instrumental acquisition, but pre-training lesions of the NAcc suggest that it is not necessary. Recently, we demonstrated that…
Descriptors: Evidence, Inhibition, Brain Hemisphere Functions, Reinforcement
Darvas, Martin; Fadok, Jonathan P.; Palmiter, Richard D. – Learning & Memory, 2011
Two-way active avoidance (2WAA) involves learning Pavlovian (association of a sound cue with a foot shock) and instrumental (shock avoidance) contingencies. To identify regions where dopamine (DA) is involved in mediating 2WAA, we restored DA signaling in specific brain areas of dopamine-deficient (DD) mice by local reactivation of conditionally…
Descriptors: Animals, Classical Conditioning, Genetics, Biochemistry
Sinai, Laleh; Duffy, Steven; Roder, John C. – Learning & Memory, 2010
The Src protein tyrosine kinase plays a central role in the regulation of N-methyl-d-aspartate receptor (NMDAR) activity by regulating NMDAR subunit 2B (NR2B) surface expression. In the amygdala, NMDA-dependent synaptic plasticity resulting from convergent somatosensory and auditory inputs contributes to emotional memory; however, the role of Src…
Descriptors: Brain Hemisphere Functions, Biochemistry, Auditory Stimuli, Role
Gryczynski, Jan; Ward, Brian W. – Health Education & Behavior, 2011
This study investigated the social dynamics that underlie the negative association between religiosity and cigarette use among U.S. adolescents. Using data from the 2007 National Survey on Drug Use and Health, the authors used a theory-based conceptual model (vicarious learning networks [VLN]) to examine the role that key reference group norms…
Descriptors: Socialization, Reference Groups, Smoking, Health Behavior
Lazzaro, Stephanie C.; Hou, Mian; Cunha, Catarina; LeDoux, Joseph E.; Cain, Christopher K. – Learning & Memory, 2010
Norepinephrine receptors have been studied in emotion, memory, and attention. However, the role of alpha1-adrenergic receptors in fear conditioning, a major model of emotional learning, is poorly understood. We examined the effect of terazosin, an alpha1-adrenergic receptor antagonist, on cued fear conditioning. Systemic or intra-lateral amygdala…
Descriptors: Posttraumatic Stress Disorder, Conditioning, Long Term Memory, Fear
Walker, David L.; Davis, Michael – Learning & Memory, 2008
Within the amygdala, most N-methyl-D-aspartic acid (NMDA) receptors consist of NR1 subunits in combination with either NR2A or NR2B subunits. Because the particular subunit composition greatly influences the receptors' properties, we investigated the contribution of both subtypes to fear conditioning and expression. To do so, we infused the…
Descriptors: Learning Processes, Memory, Conditioning, Fear
