In contemporary society, cultivating scientific literacy among the public is imperative for informed decision-making on matters influencing general well-being. Here, we report the multifaceted activity Magnifying Minds as a collaboration between artists and scientists to enhance scientific literacy through public art. Murals as a medium for science communication are deeply rooted in their historical significance and informal accessibility. Murals, as large-scale artworks, have the transformative power to reshape public spaces and engage diverse communities, extending beyond the confines of traditional art galleries and science museums. The impact of murals can be enhanced by coupling them with informal science education activities. This article summarizes Magnifying Minds by delving into the commissioning process for a scientifically themed public mural, the mural design itself that explores the concepts of size and scale, and educational activities inspired by the artwork. These activities seamlessly blend science and art, encompassing a mural puzzle, the use of magnifiers and optical microscopes, coloring of mural panels, and leaf rubbings. By showcasing Magnifying Minds, this article aims to guide similar initiatives in communities aspiring to adopt accessible approaches to science communication and education.