In the article, we focused on the issues of measurement error and omitted confounders while conducting mediation analysis under experimental studies. Depending on informativeness of the confounders between the mediator (M) and outcome (Y), we described two approaches. When researchers are confident that primary confounders are included (e.g.,…

Background: Structural Equation Modeling (SEM) is a powerful and broadly utilized statistical framework. Researchers employ these models to dissect relationships into direct, indirect, and total effects (Bollen, 1989). These models unpack the "black box" issues within cause-and-effect studies by examining the underlying theoretical…

A linear model is often used to find the effect of a binary treatment D on a noncontinuous outcome Y with covariates X. Particularly, a binary Y gives the popular "linear probability model (LPM)," but the linear model is untenable if X contains a continuous regressor. This raises the question: what kind of treatment effect does the…

Intensive longitudinal data has been widely used to examine reciprocal or causal relations between variables. However, these variables may not be temporally aligned. This study examined the consequences and solutions of the problem of temporal misalignment in intensive longitudinal data based on dynamic structural equation models. First the impact…

The p-factor is a construct that is thought to explain and maybe even cause variation in all forms of psychopathology. Since its 'discovery' in 2012, hundreds of studies have been dedicated to the extraction and validation of statistical instantiations of the p-factor, called general factors of psychopathology. In this Perspective, we outline five…

Causal mediation analysis is a popular approach for investigating whether the effect of an exposure on an outcome is through a mediator to better understand the underlying causal mechanism. In recent literature, mediation analysis with multiple mediators has been proposed for continuous and dichotomous outcomes. In contrast, methods for mediation…

Reweighting a distribution to minimize a distance to a target distribution is a powerful and flexible strategy for estimating a wide range of causal effects, but can be challenging in practice because optimal weights typically depend on knowledge of the underlying data generating process. In this paper, we focus on design-based weights, which do…

Empirical studies often demonstrate multiple causal mechanisms potentially involving simultaneous or causally related mediators. However, researchers often use simple mediation models to understand the processes because they do not or cannot measure other theoretically relevant mediators. In such cases, another potentially relevant but unobserved…

Randomized A/B tests within online learning platforms enable us to draw unbiased causal estimators. However, precise estimates of treatment effects can be challenging due to minimal participation, resulting in underpowered A/B tests. Recent advancements indicate that leveraging auxiliary information from detailed logs and employing design-based…

Staggered adoption of policies by different units at different times creates promising opportunities for observational causal inference. Estimation remains challenging, however, and common regression methods can give misleading results. A promising alternative is the synthetic control method (SCM), which finds a weighted average of control units…

Mediation analysis plays an important role in understanding causal processes in social and behavioral sciences. While path analysis with composite scores was criticized to yield biased parameter estimates when variables contain measurement errors, recent literature has pointed out that the population values of parameters of latent-variable models…

Qualitative comparative analysis (QCA) is an influential methodological approach motivated by set theory and boolean logic. QCA proponents have developed algorithms to analyze quantitative data, in a bid to uncover necessary and sufficient conditions where causal relationships are complex, conditional, or asymmetric. This article uses computer…

Evaluating blocked randomized experiments from a potential outcomes perspective has two primary branches of work. The first focuses on larger blocks, with multiple treatment and control units in each block. The second focuses on matched pairs, with a single treatment and control unit in each block. These literatures not only provide different…

Two approaches to causal inference in the presence of non-random assignment are presented: The Propensity Score approach which pseudo-randomizes by balancing groups on observed propensity to be in treatment, and the Endogenous Treatment Effects approach which utilizes systems of equations to explicitly model selection into treatment. The three…

Temporality-driven covariate classification had limited impact on: the specification of directed acyclic graphs (DAGs) by 85 novice analysts (medical undergraduates); or the risk of bias in DAG-informed multivariable models designed to generate causal inference from observational data. Only 71 students (83.5%) managed to complete the…