Proteomics, or the study of the set of proteins in an organism, tissue, or cell, is a rapidly growing field within bioanalytical chemistry that can be used to investigate many biological questions. However, proteomics is not fully integrated into the undergraduate chemistry curriculum because of a lack of access to expertise, the cost of required…

Three computer-based activities focusing on fundamentals of binding interactions are described that are powered by Desmos, freely available web-based software. The software allows the instructor to monitor the progress of each student completing the activity by privately viewing their answers in real time, to enforce class pacing by modulating…

Jordan canonical form (JCF) is one of the most important, and useful, concepts in linear algebra. Mathematics, physics, biology, science and engineering undergraduates often find the first application of real JCF in the discipline of differential equations (continuous models) to solving systems of differential equations. In this work, we apply…

Ion channel sensors have several applications including DNA sequencing, biothreat detection, and medical applications. Ion channel sensors mimic the selective transport mechanism of cell membranes and can detect a wide range of analytes at the molecule level. Analytes are sensed through changes in signal patterns. Papers in the literature have…

Retrieval practice is an evidence-based approach to teaching; here, we evaluate the use of PeerWise for embedding retrieval practice into summative assessment. PeerWise allows anonymous authoring, sharing, answering, rating, and feedback on peer-authored multiple choice questions. PeerWise was embedded as a summative assessment in a large…

This study aimed to critically evaluate the information provided by ChatGPT on the role of lactate in fatigue and muscle pain during physical exercise. We inserted the prompt "What is the cause of fatigue and pain during exercise?" using ChatGPT versions 3.5 and 4o. In both versions, ChatGPT associated muscle fatigue with glycogen…

Designing a relevant and engaging curriculum for biochemistry undergraduates can be challenging for topics which are at the periphery of the subject. We have used the framework of context-based learning as a means of assessing understanding of quantum theory in a group of students in their junior year. Our context, the role of retinol in skincare,…

Accurate assessment of saliva sampling time is essential for studies that collect cortisol sample in ambulatory settings. This study examined the sampling time assessed by user-submitted photos via a mobile application (ZEMI) compared with MEMSCaps™. Intra-class correlation coefficient (ICC) of the time differences between when the 16 adolescents…

Having a deeper understanding of molecules in their structural forms allows students to grasp biochemical and general chemical concepts in a more profound manner. Through the use of visualization software, we have shown that students gain confidence and insight into the chemical workings of molecular structure and can then utilize this knowledge…

Background: Traditional teaching methods of biochemistry provide effective tools for knowledge transmission, but are considered less engaging with students. Smartphone applications may provide suitable alternatives to compensate for the shortcomings of traditional teaching methods. Purpose: This study aimed to assess the effectiveness of…

Dimensionality reduction techniques are essential in analyzing large 'omics' datasets in biochemistry and molecular biology. Principal component analysis, t-distributed stochastic neighbor embedding, and uniform manifold approximation and projection are commonly used for data visualization. However, these methods can be challenging for students…

The effective and responsible educational application of ChatGPT and other generative artificial intelligence (GenAI) tools constitutes an active area of exploration. This study describes and assesses the implementation of a structured, GenAI-assisted scientific essay writing assignment in nucleic acid biochemistry. Briefly, students created,…

The COVID-19 pandemic has forced a shift in thinking regarding the safe delivery of wet laboratory courses. While we were fortunate to have the capacity to continue delivering wet laboratory experiments with physical distancing and other measures in place, modifications to the mechanisms of delivery within courses were necessary to minimize risk…

A Microsoft Excel workbook has been developed to simplify the quantitative analysis of experimentally measured titration curves for diprotic and triprotic amino acids such as glycine, arginine, histidine, and glutamate. Students perform the titration, enter the data into the worksheet, and manually adjust the resulting pK[subscript a] values to…

A software to calculate the net charge and to predict the isoelectric point (pI) of a polypeptide is developed in this work using the graphical programming language LabVIEW. Through this instrument the net charges of the ionizable residues of the chains of the proteins are calculated at different pH values, tabulated, pI is predicted and an Excel…