Student engagement in evidence-based argumentation plays a central role in science education. These skills can be developed when identifying organic molecules from the spectroscopic data. Molecular structural analysis fosters deep procedural knowledge, as it involves (i) flexibly applying a set of procedures to extract information from spectra,…

We have developed a guided-inquiry laboratory exercise in which students perform viscosity measurements to infer the structure of poly(vinyl alcohol) (PVA) in aqueous solution. The activity combines both experiments and modeling. In the experimental portion of the exercise, students measure the viscosity of several solutions of PVA with differing…

NMR prediction using ChemDoodle, NMR calculation with Gaussian, and hands-on data collection using a benchtop NMR spectrometer were explored to assess their synergistic capacity in teaching NMR to organic chemistry students. Nine molecules representing functional groups commonly encountered in undergraduate organic chemistry were selected. Spectra…

A [beta]-lactam, the core structure unit of clinically important antibiotics such as penicillin and cephalosporin, is one of the most commonly encountered four-membered heterocycles in organic chemistry and is widely used in medicine and biochemistry. The Kinugasa reaction, a copper­(I)-catalyzed cycloaddition of a terminal alkyne with a nitrone,…

Using crystal structure data, site directed mutagenesis, and real-time kinetic assays, students designed, expressed, and purified engineered mutants of human insulin-degrading enzyme (IDE). Students designed their own IDE mutants following "in silico" analysis, used inverse PCR to generate mutant plasmid expression constructs, expressed…

Catalysis and catalytic cycles are widely used in both research and industry. The addition of a catalysis experiment into the undergraduate laboratory curriculum is important and necessary training to expand student learning. Here, an experiment demonstrating iron-based tandem catalysis was developed and implemented in an organic chemistry course…

Having a deeper understanding of molecules in their structural forms allows students to grasp biochemical and general chemical concepts in a more profound manner. Through the use of visualization software, we have shown that students gain confidence and insight into the chemical workings of molecular structure and can then utilize this knowledge…

Nanoparticle Zn[subscript 2x] Cu[subscript 1-x] In[subscript 1-x] S[subscript 2] is a promising and safer alternative to lead- and cadmium-containing quantum dots. Students prepare Zn[subscript 0.44] Cu[subscript 0.78] In[subscript 0.78] S[subscript 2] quantum dots in a one-pot synthesis without an inert atmosphere and investigate how the color,…

According to the definition, surface tension could be affected not only by intermolecular interaction but also by molecular area. However, in chemistry textbooks, surface tension is mainly explained only in terms of intermolecular interaction. Although the existing surface tension concept in the textbooks can lead to a variety of counterexamples,…

Some science subjects are often perceived to be difficult and boring by students due to their nature and the way they are taught. This study sought to check the effectiveness of the technology-enhanced instruction method with comprehensive use of virtual labs and animations in teaching nerve cells' (neurons and glial cells) structures and…

Molecular symmetry plays a central role in chemistry education with regard to predicting chemical properties such as bonding and spectroscopic transitions. Better understanding of the symmetry of molecules requires high visual-spatial thinking ability. Conventional teaching methodologies, with limited teaching aides, fall short in providing a…

A procedure for the study of structural differences and intermolecular attraction between ethanol and 1-butanol based in laboratory work is described. This study provides comparisons of data retrieved from both a determination of boiling point and gas chromatography traces for the mixture. The methodology reported here should provide instructors…

The increasing industrial and biomedical applications of nanomaterials have enhanced the need to educate a well-trained nanotechnology workforce. This need has led to efforts to introduce hands-on, nanotechnology-based, experimental modules into high school and college level courses in science and engineering. However, the majority of such efforts…

A laboratory is a large investment of time and money for departments of chemistry yet discussions continue about its purpose in the educational process. Helping students navigate the three levels of representation; macroscopic, particulate and symbolic is a potential use of this time. This study looked at two different types of visualization for…

Clustered regularly interspaced short palindromic repeats (CRISPRs) represent a novel type of adaptive immune system found in eubacteria and archaebacteria. CRISPRs have recently generated a lot of attention due to their unique ability to catalog foreign nucleic acids, their ability to destroy foreign nucleic acids in a mechanism that shares some…