A vibrant and sustainable research environment is essential to establish a thriving PhD program. Organization for PhD Education in Health Sciences in European System, a European platform to promote best practices in PhD education in health sciences, published a guideline entitled "Best Practices for PhD Training." The guideline includes comprehensive recommendations and suggestions on different components of the PhD program, of which supervision is an essential one. A working supervisor-student relationship based on mutual respect, responsibility, and participation is essential for the success of a PhD thesis. Supervisors should be active researchers and receive training to develop their supervising skills. They serve as role models in academic life, both scientifically and ethically. The appointment of a co-supervisor, besides the principal one, is strongly encouraged not only to increase the efficiency in monitoring the student progression but also to defuse interpersonal conflicts. Institutional regulations should include the duties and responsibilities of the supervisor. A contract prepared by the institution and signed by the supervisor and the student could help specify the task and may serve as a starting point. In case of a conflict, grievance mechanisms also need to be clear and explicit. Supervisors ought to assist the career development of the students and guide them to become independent researchers. Unfortunately, different surveys showed that there is widespread discontent among the students about their supervisors. Performance pressure on both students and supervisors create enormous tension. Students feel stressed about their career prospects. Institutional policies should consider these stress points to enhance the wellbeing of students as well as the faculty. [Paper presented at the joint International Union of Biochemistry and Molecular Biology (IUBMB) Education Conference and Philippine Society of Biochemistry and Molecular Biology (PSBMB) Annual Convention (46th) (Manila City, Philippines, Nov 13-15, 2019).]