This study was conducted to investigate the effectiveness of an international teaching practicum (ITP) in terms of reinforcing the student-teachers' multicultural knowledge competence through ITP participation. The data were collected from three surveys at three different points in time: before the ITP, after the ITP domestic pre-orientation programme, and after the completion of the ITP. The participants of this study were 32 students at G university who were finishing their 2nd and 3rd years. The collected data were analysed with SPSS 23.0. This research shows the effectiveness of ITP in terms of enhancing student-teachers' multicultural knowledge competence. It also shows the importance of domestic pre-orientation before participation in an overseas on-site teaching practicum.