This paper is a systematic review of empirical research on "tourism problems and entrepreneurship development" in the context of Vietnam. Its significance and urgency rest upon a prolonged and immense decline in Vietnam's tourism revenue due to COVID-19 pandemic restrictions and its stagnation of tourism recovery. The systematic review methodology provides rigorous procedures to achieve reliable and accurate results. Besides evaluating and identifying gaps in existing studies, tourism problems are discussed, and coherent resolutions are provided. As a result, a holistic picture of current studies and relevant approaches to tourism entrepreneurship development in Vietnam is projected.