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Barrett, Rowland P.; And Others – American Journal on Mental Retardation, 1989
Double blind study compared effects of two drug treatments, naloxone hydrochloride and naltrexone hydrochloride, on self-injurious behavior of a 12-year-old mentally retarded and autistic girl. Self-injury increased with naloxone treatment but decreased to near zero with naltrexone, a change which persisted at follow-up 22 months after treatment.…
Descriptors: Autism, Drug Therapy, Maintenance, Mental Retardation
Peer reviewed
Direct linkShapira, Nathan A.; Lessig, Mary C.; Lewis, Mark H.; Goodman, Wayne K.; Driscoll, Daniel J. – American Journal on Mental Retardation, 2004
Prader-Willi syndrome is a multisystem neurogenetic obesity disorder with behavioral manifestations, including hyperphagia, compulsive behavior, self-injury, and mild to moderate mental retardation. In an 8-week open-label study, we evaluated adjunctive therapy with the anticonvulsant topiramate in 8 adults with Prader-Willi syndrome. Appetite was…
Descriptors: Obesity, Moderate Mental Retardation, Adults, Eating Disorders
