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Connecting Common Genetic Polymorphisms to Protein Function: A Modular Project Sequence for Lecture or Lab
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Berndsen, Christopher E.; Young, Byron H.; McCormick, Quinlin J.; Enke, Raymond A. – Biochemistry and Molecular Biology Education, 2016
Single nucleotide polymorphisms (SNPs) in DNA can result in phenotypes where the biochemical basis may not be clear due to the lack of protein structures. With the growing number of modeling and simulation software available on the internet, students can now participate in determining how small changes in genetic information impact cellular…
Descriptors: Biochemistry, Genetics, Science Instruction, Sequential Approach
Two-Dimensional Nuclear Magnetic Resonance Structure Determination Module for Introductory Biochemistry: Synthesis and Structural Characterization of Lyso-Glycerophospholipids
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Garrett, Teresa A.; Rose, Rebecca L.; Bell, Sidney M. – Biochemistry and Molecular Biology Education, 2013
In this laboratory module, introductory biochemistry students are exposed to two-dimensional [superscript 1]H-nuclear magnetic resonance of glycerophospholipids (GPLs). Working in groups of three, students enzymatically synthesized and purified a variety of 2-acyl lyso GPLs. The structure of the 2-acyl lyso GPL was verified using [superscript…
Descriptors: Diagnostic Tests, Science Laboratories, Biochemistry, College Science
Designing Laboratory Exercises for the Undergraduate Molecular Biology/Biochemistry Student: Techniques and Ethical Implications Involved in Personalized Medicine
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Weinlander, Kenneth M.; Hall, David J. – Biochemistry and Molecular Biology Education, 2010
Personalized medicine refers to medical care that involves genetically screening patients for their likelihood to develop various disorders. Commercial genome screening only involves identifying a consumer's genotype for a few single nucleotide polymorphisms. A phenotype (such as an illness) is greatly influenced by three factors: genes, gene…
Descriptors: Medical Services, Medicine, Genetics, Molecular Biology
Modular Laboratory Courses: An Alternative to a Traditional Laboratory Program
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Caprette, David R.; Armstrong, Sarah; Beason, K. Beth – Biochemistry and Molecular Biology Education, 2005
Our modular laboratory teaching program is characterized by two major features. First, each course is taught independently and not linked with a particular lecture course. Second, each course is designed to be completed within one-half semester or less. The modular organization has allowed incorporation of the latest technology, reduction of class…
Descriptors: Science Laboratories, Biological Sciences, Science Instruction, College Science