This research is related mainly to the study of the results on the development of digital literacy and digital empathy with micro-learning via activities on metaverse. The main concept of this study is based on the integration of micro-learning process with metaverse technology in order to encourage and provide learners with opportunities to create bodies of knowledge and engage in joint activities through the network system that can be accessed anywhere and anytime. The objectives of this research are (1) to synthesize the conceptual framework of the microlearning via activities on metaverse, (2) to design the micro-learning process via activities on metaverse, and (3) to study the results of the development of digital literacy and digital empathy with the micro-learning via activities on metaverse. Thereby, this study relies on the pre-experimental research method with one-shot case study, in which the research participants are 30 undergraduate students of Pakse Teacher Training College, Lao People's Democratic Republic, who were derived by means of cluster sampling and well protected under the policy of confidentiality and anonymity. The research results show that (1) the students' digital literacy and digital empathy, after learning with the micro-learning via activities on metaverse, are at very good level (mean = 43.20, SD = 2.35), and (2) the overall satisfaction towards the micro-learning via activities on metaverse is at high level (mean = 4.42, SD = 0.78). In reference to the above research results, it is evident that the micro-learning via activities on metaverse enables the students to quickly develop their digital literacy and digital empathy after receiving new experiences and new knowledge because the knowledge gained from the learning of this style is easy to remember and can be applied in an effective manner.