A lack of student questioning is faced by many universities, where a large lecture is a common practice. Emerging technologies bring about possibilities to fill this gap. This study followed constructivist learning theory and used a digital canvas as a Digital Question Board (DQB) for students to freely pose questions and respond using mobile technology. A mixed-methods study with a quasi-experiment was conducted to investigate its effect. The study was conducted in two sections of an introductory research methodology course in a large comprehensive university in eastern China (n = 253). The pre-post quasi-experiment lasted six weeks. The data from surveys, observation, and online posts (log data) revealed that when the instructor discussed student questions after every 20-30 min in large lecture classes, students with DQB access had a significantly higher frequency of questioning than those without a DQB. The presence of the DQB enriched the types of questions and responses and encouraged mostly on-task learning questions. With technology, students employed a non-linear, constructivist questioning process and actively contributed to the co-construction of knowledge.