The aim of the research is to provide a general framework for POE used in biology education using meta-synthesis. In this research; studies on the use of the prediction-observation-explanation (POE) in biology education between the years 2000-2020 in Turkey and the World have been examined considering research type, distribution of the studies by years, the preferred research groups, the research methods used, the data collection tools used and the subject areas. The researches included in the research were obtained in Turkish and English by systematically scanning the literature covering the years 2000-2020 from the Google search engine, Web of Science, ERIC database, Google Academic Search, The Scientific and Technological Research Council of Turkey (ULAKBIM) database, ProQuest dissertation database and Higher Education Council's (HEC) National dissertation center. 27 studies were reached within the framework of inclusion criteria. It has been determined that the studies are distributed as 21 article, 5 master thesis and 1 doctoral dissertation according to the research type. Obtained data were interpreted on the basis of the frequency and were sometimes indicated with tables and graphs. According to the consequences; it was stated that most of the studies were in the type of research, pre-service teachers were preferred more than other samples, quantitative studies were more than qualitative studies, academic achievement tests were used the most as data collection tool and "Diffusion-Osmosis" subjects was studied the most.