Peer reviewed
Direct linkERIC Number: EJ1262944
Record Type: Journal
Publication Date: 2020-Sep
Pages: 6
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-1360-2322
EISSN: N/A
Available Date: N/A
Ageing and Cognition in Men with Fragile X Syndrome
Sauna-aho, Oili; Bjelogrlic-Laakso, Nina; Rautava, Päivi; Arvio, Maria
Journal of Applied Research in Intellectual Disabilities, v33 n5 p1113-1118 Sep 2020
Background: Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability. The aim of our longitudinal study was to describe ageing-related cognitive changes in men with FXS. Method: A neuropsychologist determined the raw scores (RSs) of 19 men with FXS twice with the Leiter International Performance Scale at an average interval of 22 years. The ages of the participants at baseline ranged from 16 to 50 (mean 27) years. Results: At follow-up, the RSs improved in two men, remained the same in two men and declined in 15 men. Overall, the RS of the study group deteriorated by an average 4 points in RSs (p < 0.001). Conclusion: Cognitive ageing in men with FXS started earlier than that in men in the general population; in many cases, cognitive ageing in men with FXS began before middle age, usually without any medical or other underlying cause.
Descriptors: Aging (Individuals), Schemata (Cognition), Males, Intellectual Disability, Longitudinal Studies, Raw Scores, Neuropsychology, Adolescents, Adults, Cognitive Ability
Wiley. Available from: John Wiley & Sons, Inc. 111 River Street, Hoboken, NJ 07030. Tel: 800-835-6770; e-mail: cs-journals@wiley.com; Web site: https://www.wiley.com/en-us
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Identifiers - Assessments and Surveys: Leiter International Performance Scale
Grant or Contract Numbers: N/A
Author Affiliations: N/A
