Background: Adult ADHD has increasingly become a focus in adult psychiatry. Despite well-established diagnostic criteria and specific therapeutic approaches, contemporary discussions often dismiss ADHD as a "fad." This study examines Carl Gustav Jung's 1904 concept of "manic mood" and its potential alignment with the modern…

Objective: To examine the effects of triple beaded mixed amphetamine salts (TB MAS) on ADHD and executive dysfunction symptoms throughout the day in adults with DSM-5 ADHD. Method: This was a 6 week, single-blind, placebo-lead in trial of TB MAS (12.5-37.5 mg/day); all participants received 2 weeks of single-blind placebo); one individual was a…

Objective: In this study, to investigate the place of T cell-mediated immunity in the etiology of ADHD, for which we do not have enough information; we aimed to investigate the activity of DPP IV and ADA, which are T cell-related enzymes, and the relationship of these enzymes with ADHD symptoms in children with ADHD. Methods: Twenty-seven children…

Objective(s): To assess the likelihood of ADHD diagnosis in children of non-US-born caregivers relative to children of US-born caregivers. Method: Cross-sectional analysis of a combined 2016 to 2019 National Survey of Children's Health dataset (n = 109,881) was performed to identify associations between caregiver's birth outside the U.S. and…

Background: ADHD is a generally persistent neurodevelopmental condition that can have significant consequences if left untreated, and medication, often in conjunction with psychotherapy, is the first-line treatment with well-established efficacy. Adolescents and young adults (AYAs) represent a particularly vulnerable and understudied subgroup and…

Objective: Neurotypical individuals can prioritize particularly valuable information in working memory. This is a well-replicated effect, demonstrated across a wide variety of task factors and age groups. However, it is not clear if individuals with symptoms of ADHD are able to do this effectively, as there is some evidence this group struggle to…

Background: Lipid metabolism plays an essential role in nervous system development. Cholesterol deficiency leads to a variety of neurodevelopmental disorders, such as autism spectrum disorder and fragile X syndrome. There have been a lot of efforts to search for biological markers associated with and causal to ADHD, among which lipid is one…

Objective: Given the complex nature of seizure disorders and their treatments, ADHD may be underdiagnosed in this population. We hypothesized that a higher percentage of patients presenting to a seizure clinic would endorse ADHD symptoms compared to rates reported in the general population and that formal screening for ADHD symptoms would identify…

Background and Aim: "Crocus sativus" also known as saffron, is one of the most popular traditional plants. This study aims to evaluate the efficacy and safety of saffron extracts in ADHD. Method: This study includes clinical trial studies that assessed the efficacy and/or safety of saffron in ADHD patients. Non-English papers, review…

Background: ADHD and ASD are associated with dermatologic manifestations, yet little research investigates cooccurring ADHD/ASD and common dermatologic conditions. Objective: To investigate associations between ADHD, ASD, acne vulgaris, and atopic dermatitis. Methods: Using de-identified patient records from the TriNetX database, we created four…

Background: ADHD and alcohol use are prevalent among college students, but few studies have examined internal restlessness (i.e., the mental discomfort experienced when suppressing hyperactive behaviors) in relation to alcohol use. Consequently, the current study sought to examine a path model testing associations between internal restlessness,…

Objective: Maladaptive daydreaming (MD) is an impairing condition characterized by addiction to narrative, emotional fantasizing, involving dissociative absorption. By compulsively withdrawing toward vivid imaginative scenarios, MD hinders attentional functioning and replaces social interactions. Previous Interview-based research showed clinical…

Objective: This study aimed to objectively assess signs of hyperactivity in adults suspected of having ADHD, addressing potential sex bias in diagnosis. Methods: About 13,179 (49% female) adults with an average age of 33 years with ADHD and 1,910 (41% female) adults with an average age of 36 years without ADHD were included. Motor activity was…

Background: Research examining the potential effects of stimulant exposure in childhood on subsequent development of substance use disorder (SUD) have focused on differences in the brain reward system as a function of risk. Methods: 18 drug naïve children ages 7 to 12 years (11 High Risk [ADHD + ODD/CD]; 7 Low Risk [ADHD only]), underwent fMRI…

Objective: There is growing evidence of involvement of inflammatory mechanisms in ADHD. Previous studies found significantly higher rates of ADHD among children with FMF. The present study examined the rate of exposure to FMF in children with a later (within a 5-year period) diagnosis of ADHD compared to non-ADHD children. Methods: A…