Clinical histories and physical findings are presented for 2 sisters with Rett syndrome. The older sister, age 25, was typically affected, whereas the younger sister, 22 years old, was affected with a seizure disorder showing an unusually early onset. The paper discusses hypotheses in genetic causation of Rett syndrome. (JDD)

The follow-up study of 16 nonretarded autistic children as adults found that, though most were functioning poorly in terms of occupational-social outcome and psychiatric symptoms, four had essentially recovered. Severity of early autistic behavior was a poor predictor of outcome, but neuropsychologic measures of nonverbal problem solving were…

Six autistic children, age 3-6, and 6 children with Down syndrome were followed over a period of 12-26 months. Autistic children followed the same general developmental path as the Down syndrome children in the acquisition of grammatical and lexical aspects of language. (Author/JDD)

Naltrexone hydrochloride was administered to an autistic mentally retarded male, age 14, to investigate the endogenous opiate release theory of self-injurious behavior (SIB). Results yielded a marked decrease in SIB and increased social relatedness during two phases of drug treatment. SIB did not revert to original placebo levels during a second…

Compared to age-matched and language-matched controls, 15 autistic children (mean age of 45 months) who were administered the Early Social-Communication Scales displayed deficits in gestural joint attention skills in 2 testing sessions 13 months apart. The measure of gestural nonverbal joint attention predicted language development in subjects.…

When two nonhandicapped peers of an autistic five-year old were trained to initiate social interaction, social interaction increased and then dramatically decreased in a reversal phase, and no decrease in the autistic child's disruptive behaviors was observed. When the autistic child was trained to initiate interaction, social interaction…

This report presents case studies of 4 adults with autism who enrolled in a work-training program utilizing a behavioral social interaction approach, and were subsequently competitively employed for 6 to 30 months. Success was associated with such factors as appropriate communication and interpersonal skills, gradual fading of supervision, and…