Describes the use of risperidone in eight adult patients with moderate to profound mental retardation and markedly aberrant behaviors. Risperidone in these individuals was associated with significant reduction in aggression and self-injurious behavior. Side effects were primarily those of sedation and restlessness. (Author/CR)

This study reports marked reductions in self-injurious behavior and aggression of two adults with profound mental retardation treated with clozapine, who were non-responsive to all other behavioral and psychopharmacological interventions, including risperidone. The most effective dose was 200mg/day. Side effects were mild and the drug was…

Presents information on 24 and 34 months of successful treatment with Risperidone of a young woman and young man with autism and profound mental retardation. Treatment with Risperidone resulted in positive changes for aggressive, self-injurious, and anti-social behavior. After treatment, subjects were able to participate in social activities. (CR)

In two experiments with profoundly retarded institutionalized individuals, 10 severely aggressive, hyperactive young adults were exposed to two daily periods of jogging and strenuous physical activities. Results indicated systematic reductions in problem behavior for eight of the 10 to levels considered "not a problem" or only "an occasional…