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Direct linkHickman, Allison R.; Selee, Bradley; Pauly, Rini; Husain, Benafsh; Hang, Yuqing; Feltus, Frank Alex – Journal of Autism and Developmental Disorders, 2023
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by challenges in social communication as well as repetitive or restrictive behaviors. Many genetic associations with ASD have been identified, but most associations occur in a fraction of the ASD population. Here, we searched for eQTL-associated DNA variants with…
Descriptors: Genetics, Autism Spectrum Disorders, Brain, Biochemistry
Andreo-Martínez, Pedro; Rubio-Aparicio, María; Sánchez-Meca, Julio; Veas, Alejandro; Martínez-González, Agustín Ernesto – Journal of Autism and Developmental Disorders, 2022
Previous studies have reported dysbiosis in the gut microbiota (GM) of children with autism spectrum disorders (ASD), which may be a determining factor on child development through the microbiota-gut-brain axis. However, it is not clear if there is a specific group of dysbiotic bacteria in ASD. The aim of this study was to carry out a…
Descriptors: Children, Autism, Pervasive Developmental Disorders, Microbiology
Gokce Guldiken; Ali Karayagmurlu; Canan Kucukgergin; Murat Coskun – Journal of Autism and Developmental Disorders, 2024
Purpose: To investigate serum levels of VEGF, IGF-1 and FGF-2, and relationships with several clinical characteristics in children and adolescents with autism spectrum disorder (ASD) with and without bipolar disorder (BD). Method: 40 subjects with ASD + BD as study group, and 40 subjects with ASD as control group were included. Serum levels of…
Descriptors: Children, Adolescents, Autism Spectrum Disorders, Mental Disorders
Carey, Meghan E.; Rando, Juliette; Melnyk, Stepan; James, S. Jill; Snyder, Nathaniel; Salafia, Carolyn; Croen, Lisa A.; Fallin, M. Daniele; Hertz-Picciotto, Irva; Volk, Heather; Newschaffer, Craig; Lyall, Kristen – Journal of Autism and Developmental Disorders, 2023
We examined associations between prenatal oxidative stress (OS) and child autism-related outcomes. Women with an autistic child were followed through a subsequent pregnancy and that younger sibling's childhood. Associations between glutathione (GSH), glutathione disulfide (GSSG), 8-oxo-deoxyguanine (8-OHdG), and nitrotyrosine and younger sibling…
Descriptors: Physiology, Prenatal Influences, Autism Spectrum Disorders, Pregnancy
Wen-Xiong Chen; Yi-Ru Chen; Min-Zhi Peng; Xian Liu; Yan-Na Cai; Zhi-Fang Huang; Si-Yuan Yang; Jing-Yu Huang; Ruo-Han Wang; Peng Yi; Li Liu – Journal of Autism and Developmental Disorders, 2024
To retrospectively explore the characteristics of plasma amino acids (PAAs) in children with autism spectrum disorder and their clinical association via case-control study. A total of 110 autistic and 55 healthy children were recruited from 2014 to 2018. The clinical phenotypes included severity of autism, cognition, adaptability, and regression.…
Descriptors: Autism Spectrum Disorders, Severity (of Disability), Foreign Countries, Comparative Analysis
Magdalini Asaridou; Ericka L. Wodka; Richard A. E. Edden; Stewart H. Mostofsky; Nicolaas A. J. Puts; Jason L. He – Journal of Autism and Developmental Disorders, 2024
Sensory differences are highly prevalent in autistic individuals. However, few studies have compared their presentation between autistic males and autistic females. We used psychophysics to assess and compare tactile perceptual sensitivity between autistic and non-autistic boys and girls aged between 8 and 12 years of age. While there were…
Descriptors: Children, Autism Spectrum Disorders, Control Groups, Sensory Experience
Keim, Sarah A.; Jude, Abigail; Smith, Katie; Khan, Aiman Q.; Coury, Daniel L.; Rausch, Joseph; Udaipuria, Shivika; Norris, Megan; Bartram, Lindsay R.; Narayanan, Anita R.; Rogers, Lynette K. – Journal of Autism and Developmental Disorders, 2022
This double-blind, randomized controlled trial, tested fatty acid (FA) supplementation in children (ages 2- < 6 years) recently diagnosed with Autism Spectrum Disorder (ASD). Participants received daily oral FA supplement containing omega-3 and omega-6 FA, or a placebo for 90 days based on participant weight. Erythrocyte FAs and the cytokines,…
Descriptors: Young Children, Autism Spectrum Disorders, Human Body, Child Health
Horinouchi, Tomoko; Maeyama, Kaori; Nagai, Masashi; Mizobuchi, Masami; Takagi, Yasuko; Okada, Yuka; Kato, Takeshi; Nishimura, Mio; Kawasaki, Yoko; Yoshioka, Mieko; Takada, Satoshi; Matsumoto, Hisayuki; Nakamachi, Yuji; Saegusa, Jun; Fukushima, Sachiyo; Fujioka, Kazumichi; Tomioka, Kazumi; Nagase, Hiroaki; Nozu, Kandai; Iijima, Kazumoto; Nishimura, Noriyuki – Journal of Autism and Developmental Disorders, 2022
Neonatal jaundice has been suggested as a perinatal risk factor for autism spectrum disorder (ASD). We examined UGT1A1 polymorphisms to assess the potential of neonatal jaundice as a risk factor for ASD in children by using DNA extracted from preserved umbilical cord. In total, 79 children with ASD were genotyped for "UGT1A1*28"…
Descriptors: Neonates, Physiology, Biochemistry, Children
Palm, Camilla V. B.; Glintborg, Dorte; Find, Laura G.; Larsen, Pia V.; Dalgaard, Cilia M.; Boye, Henriette; Jensen, Tina K.; Dreyer, Anja F.; Andersen, Marianne S.; Bilenberg, Niels – Journal of Autism and Developmental Disorders, 2023
Fetal androgen exposure may be associated with autism spectrum disorder (ASD). We studied 1777 mother-child pairs in the prospective Odense Child Cohort. Prenatal androgen exposure was assessed by maternal 3rd trimester testosterone concentrations, maternal polycystic ovary syndrome (PCOS), and 3 months offspring anogenital distance. ASD traits…
Descriptors: Prenatal Influences, Autism Spectrum Disorders, Correlation, Mothers
Gallardo-Carrasco, Maria Carmen; Jiménez-Barbero, José Antonio; Bravo-Pastor, María del Mar; Martin-Castillo, David; Sánchez-Muñoz, María – Journal of Autism and Developmental Disorders, 2022
Vitamin and fatty acid deficiency in children diagnosed with autism has been linked to the etiology and course of the disease but the results have been inconsistent. In our work, we present a narrative review, which includes 20 observational studies that provide data on the blood levels of vitamin D, folate, or fatty acids of children diagnosed…
Descriptors: Biochemistry, Autism Spectrum Disorders, Meta Analysis, Comparative Analysis
Wang, Lei; Zheng, Ruixuan; Xu, Ying; Zhou, Ziyun; Guan, Ping; Wu, Yanling; Zhou, Jian; Cheng, Zaohuo; Zhang, Lili – Journal of Autism and Developmental Disorders, 2022
Autism Spectrum Disorder (ASD) is a serious neurodevelopmental disorder with no clinical biomarker. This study used untargeted metabolomic analysis to identify metabolic characteristics in plasma that can distinguish ASD children. 29 boys with ASD (3.02 ± 0.67 years) and 30 typically developing (TD) boys (3.13 ± 0.46 years) were recruited.…
Descriptors: Males, Autism Spectrum Disorders, Control Groups, Biochemistry
Zuniga-Kennedy, Miranda; Davoren, Micah; Shuffrey, Lauren C.; Luna, Ruth Ann; Savidge, Tor; Prasad, Vinay; Anderson, George M.; Veenstra-VanderWeele, Jeremy; Williams, Kent C. – Journal of Autism and Developmental Disorders, 2022
Hyperserotonemia, or elevated levels of whole blood serotonin (WB5-HT), was the first biomarker linked to autism spectrum disorder (ASD). Despite numerous studies investigating the etiology of hyperserotonemia, results have been inconsistent. Recent findings suggest a relationship between the immune system and hyperserotonemia. The current study…
Descriptors: Children, Autism, Pervasive Developmental Disorders, Biochemistry
Abel, Emily A.; Schwichtenberg, A. J.; Mannin, Olivia R.; Marceau, Kristine – Journal of Autism and Developmental Disorders, 2020
Sleep disorders (SD) are common in autism spectrum disorder (ASD), yet relatively little is known about the potential genetic mechanisms involved in SD and ASD comorbidity. The current study begins to fill this gap with a gene enrichment study that (1) identifies risk genes that contribute to both SD and ASD which implicate circadian entrainment,…
Descriptors: Genetics, Sleep, Autism, Pervasive Developmental Disorders
Çelikkol Sadiç, Çagla; Bilgiç, Ayhan; Kilinç, Ibrahim; Oflaz, Mehmet Burhan; Baysal, Tamer – Journal of Autism and Developmental Disorders, 2021
This study aimed to investigate the role of leptin, ghrelin, neuropeptide Y, and nesfatin-1 in young children with autism spectrum disorder (ASD). A total of 44 children with ASD and 44 healthy controls aged 18-60 months were included. Plasma levels of hormones were measured using commercial enzyme-linked immunosorbent assay kits. Plasma leptin…
Descriptors: Young Children, Autism, Pervasive Developmental Disorders, Toddlers
Burke, Shanna L.; Cobb, Jessica; Agarwal, Rumi; Maddux, Marlaina; Cooke, Marcus S. – Journal of Autism and Developmental Disorders, 2021
Growing interest in the pathogenesis of autism spectrum disorders (ASDs) and other intellectual and developmental disabilities (IDD) has led to emerging evidence implicating a role for oxidative stress. However, understanding the strength of this association is made challenging by the use of a variety of purported biomarkers of oxidative stress,…
Descriptors: Stress Variables, Intellectual Disability, Autism, Pervasive Developmental Disorders
