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Direct linkAbulebda, Kamal; Louer, Ryan; Lutfi, Riad; Ahmed, Sheikh Sohail – Journal of Autism and Developmental Disorders, 2018
Children with autism and autism spectrum disorders have a high incidence of neurologic comorbidities. Consequently, evaluation with magnetic resonance imaging (MRI) is deemed necessary. Sedating these patients poses several challenges. This retrospective study compared the efficacy and safety of dexmedetomidine to propofol in sedating autistic…
Descriptors: Diagnostic Tests, Brain Hemisphere Functions, Comorbidity, Patients
Saghazadeh, Amene; Rezaei, Nima – Journal of Autism and Developmental Disorders, 2017
Brain-derived neurotrophic factor (BDNF) plays an important role in activity-dependent synaptic plasticity. Altered blood BDNF levels have been frequently identified in people with autism spectrum disorders (ASD). There are however wide discrepancies in the evidence. Therefore, we performed the present systematic review and meta-analysis aimed at…
Descriptors: Meta Analysis, Brain Hemisphere Functions, Patients, Control Groups
Olincy, Ann; Blakeley-Smith, Audrey; Johnson, Lynn; Kem, William R.; Freedman, Robert – Journal of Autism and Developmental Disorders, 2016
Abnormalities in CHRNA7, the alpha7-nicotinic receptor gene, have been reported in autism spectrum disorder. These genetic abnormalities potentially decrease the receptor's expression and diminish its functional role. This double-blind, placebo-controlled crossover study in two adult patients investigated whether an investigational…
Descriptors: Patients, Autism, Pervasive Developmental Disorders, Genetics
Pagani, Marco; Manouilenko, Irina; Stone-Elander, Sharon; Odh, Richard; Salmaso, Dario; Hatherly, Robert; Brolin, Fredrik; Jacobsson, Hans; Larsson, Stig A.; Bejerot, Susanne – Journal of Autism and Developmental Disorders, 2012
Specific biological markers for Autism Spectrum Disorder (ASD) have not yet been established. Functional studies have shown abnormalities in the anatomo-functional connectivity of the limbic-striatal "social" brain. This study aimed to investigate regional cerebral blood flow (rCBF) at rest. Thirteen patients with ASD of normal intelligence and…
Descriptors: Metabolism, Autism, Intelligence Quotient, Patients
