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Brief Report: Pilot Single-Blind Placebo Lead-in Study of Acamprosate in Youth with Autistic Disorder
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Erickson, Craig A.; Wink, Logan K.; Early, Maureen C.; Stiegelmeyer, Elizabeth; Mathieu-Frasier, Lauren; Patrick, Vanessa; McDougle, Christopher J. – Journal of Autism and Developmental Disorders, 2014
Rationale: An excitatory/inhibitory (E:I) imbalance marked by enhanced glutamate and deficient gamma-aminobutyric acid (GABA) neurotransmission may contribute to the pathophysiology of autism spectrum disorders (ASD). Objectives: We report on the first single-blind placebo lead-in trial of acamprosate, a drug with putative mechanisms restoring E:I…
Descriptors: Autism, Pervasive Developmental Disorders, Drug Therapy, Metabolism
Brief Report: Social Disability in Autism Spectrum Disorder--Results from Research Units on Pediatric Psychopharmacology (RUPP) Autism Network Trials
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Scahill, Lawrence; Hallett, Victoria; Aman, Michael G.; McDougle, Christopher J.; Arnold, L. Eugene; McCracken, James T.; Tierney, Elaine; Deng, Yanhong; Dziura, James; Vitiello, Benedetto – Journal of Autism and Developmental Disorders, 2013
There is growing interest in measuring social disability as a core element of autism spectrum disorders in medication trials. We conducted a secondary analysis on the Aberrant Behavior Checklist Social Withdrawal subscale using data from two federally-funded, multi-site, randomized trials with risperidone. Study 1 included 52 subjects assigned to…
Descriptors: Autism, Pharmacology, Effect Size, Pervasive Developmental Disorders
Socio-Behavioral Characteristics of Children with Rubinstein-Taybi Syndrome
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Galera, Cedric; Taupiac, Emmanuelle; Fraisse, Sonia; Naudion, Sophie; Toussaint, Eva; Rooryck-Thambo, Caroline; Delrue, Marie-Ange; Arveiler, Benoit; Lacombe, Didier; Bouvard, Manuel-Pierre – Journal of Autism and Developmental Disorders, 2009
Research regarding the behavioral aspects of children with Rubinstein-Taybi syndrome (RTS) has suggested some possible behavioral patterns including autistic features. Caregivers of 39 children (mean age = 8.4 years) with RTS (49% showing abnormality in "CREBBP" gene) and 39 children (mean age = 8.6 years) matched on developmental level,…
Descriptors: Check Lists, Attention Span, Social Behavior, Child Behavior
Social Anxiety in High-Functioning Children and Adolescents with Autism and Asperger Syndrome
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Kuusikko, Sanna; Pollock-Wurman, Rachel; Jussila, Katja; Carter, Alice S.; Mattila, Marja-Leena; Ebeling, Hanna; Pauls, David L.; Moilanen, Irma – Journal of Autism and Developmental Disorders, 2008
We examined social anxiety and internalizing symptoms using the Social Phobia and Anxiety Inventory for Children (SPAI-C), the Social Anxiety Scale for Children -Revised (SASC-R), and the Child Behavior Checklist (CBCL) in a sample of fifty-four high-functioning subjects with autism or Asperger syndrome (HFA/AS) (M = 11.2 plus or minus 1.7 years)…
Descriptors: Check Lists, Autism, Asperger Syndrome, Child Behavior
Brief Report: Effect of Maternal Age on Severity of Autism
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Baxter, Alisa C.; Lotspeich, Linda J.; Spiker, Donna; Martin, Jacquelin L.; Grether, Judith K.; Hallmayer, Joachim F. – Journal of Autism and Developmental Disorders, 2007
The etiology of autism is complex, consisting of unknown genetic and environmental factors. Previous studies have revealed that maternal age is increased in autism compared to controls, making it a possible risk factor. This study examined the effects of maternal age on autism severity using IQ as a measure of cognitive severity and selected…
Descriptors: Severity (of Disability), Etiology, Child Behavior, Check Lists
The Modified Checklist for Autism in Toddlers: An Initial Study Investigating the Early Detection of Autism and Pervasive Developmental Disorders.
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Robins, Diana L.; Fein, Deborah; Barton, Marianne L.; Green, James A. – Journal of Autism and Developmental Disorders, 2001
The Modified Checklist for Autism in Toddlers (M-CHAT), consisting of 23 yes/no items, was used to screen 1,293 children. Of the 58 given a diagnostic/developmental evaluation, 39 were diagnosed with autism. Six items pertaining to social relatedness and communication provided the best means of discrimination among children. (Contains references.)…
Descriptors: Autism, Check Lists, Early Identification, Early Intervention
Commentary: The Modified Checklist for Autism in Toddlers.
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Charman, Tony; Baron-Cohen, Simon; Baird, Gillian; Cox, Antony; Wheelwright, Sally; Swettenham, John; Drew, Auriol – Journal of Autism and Developmental Disorders, 2001
This article comments on results of a study (EC 629 869) on the reliability of the Modified Checklist for Autism in Toddlers (M-CHAT), a early detection screening test. It discusses concerns relating to clinic vs. population samples, data analysis, use of a parent questionnaire only to identify autism, and the age of screening. (Contains…
Descriptors: Autism, Check Lists, Early Identification, Early Intervention
Reply to Charman et al.'s Commentary on the Modified Checklist for Autism in Toddlers.
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Robins, Diana L.; Fein, Deborah; Barton, Marianne L.; Green, James A. – Journal of Autism and Developmental Disorders, 2001
This article responds to comments (EC 629 869-70) on a study on the reliability of the Modified Checklist for Autism in Toddlers (M-CHAT), a early detection screening test. It addresses concerns relating to clinic vs. population samples, data analysis, use of a parent questionnaire only to identify autism, and the age of screening. (Contains 6…
Descriptors: Autism, Check Lists, Early Identification, Early Intervention
Parental Report of Social Behaviors in Autistic Preschoolers.
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Stone, Wendy L.; Lemanek, Kathleen L. – Journal of Autism and Developmental Disorders, 1990
Parents of 20 children with autism and 14 children with mental retardation, with comparable cognitive developmental levels, completed the Preschool Social Behavior Checklist. Results revealed that autistic children exhibited deficits in imaginative play, peer play, and imitation skills compared to the other group, and that parents are capable of…
Descriptors: Autism, Behavior Rating Scales, Check Lists, Comparative Analysis