NotesFAQContact Us
Collection
Advanced
Search Tips
Showing all 5 results Save | Export
Autism and Phthalate Metabolite Glucuronidation
Peer reviewed Peer reviewed
Direct linkDirect link
Stein, T. Peter; Schluter, Margaret D.; Steer, Robert A.; Ming, Xue – Journal of Autism and Developmental Disorders, 2013
Exposure to environmental chemicals may precipitate autism spectrum disorders (ASD) in genetically susceptible children. Differences in the efficiency of the glucuronidation process may substantially modulate substrate concentrations and effects. To determine whether the efficiency of this pathway is compromised in children with ASD, we measured…
Descriptors: Autism, Pervasive Developmental Disorders, Environmental Influences, Hazardous Materials
Brief Report: Approaches to [Superscript 31]P-MRS in Awake, Non-Sedated Children with and without Autism Spectrum Disorder
Peer reviewed Peer reviewed
Direct linkDirect link
Erickson, Laura C.; Scott-Van Zeeland, Ashley A.; Hamilton, Gavin; Lincoln, Alan; Golomb, Beatrice A. – Journal of Autism and Developmental Disorders, 2012
We piloted a suite of approaches aimed to facilitate a successful series of up to four brain and muscle [superscript 31]Phosphorus-Magnetic Resonance Spectroscopy ([superscript 31]P-MRS) scans performed in one session in 12 "awake", non-sedated subjects (ages 6-18), 6 with autism spectrum disorders (ASD) and 6 controls. We targeted advanced…
Descriptors: Autism, Brain, Pervasive Developmental Disorders, Spectroscopy
Non-Invasive Evaluation of the GABAergic/Glutamatergic System in Autistic Patients Observed by MEGA-Editing Proton MR Spectroscopy Using a Clinical 3 Tesla Instrument
Peer reviewed Peer reviewed
Direct linkDirect link
Harada, Masafumi; Taki, Masako M.; Nose, Ayumi; Kubo, Hitoshi; Mori, Kenji; Nishitani, Hiromu; Matsuda, Tsuyoshi – Journal of Autism and Developmental Disorders, 2011
Amino acids related to neurotransmitters and the GABAergic/glutamatergic system were measured using a 3 T-MRI instrument in 12 patients with autism and 10 normal controls. All measurements were performed in the frontal lobe (FL) and lenticular nuclei (LN) using a conventional sequence for n-acetyl aspartate (NAA) and glutamate (Glu), and the…
Descriptors: Autism, Spectroscopy, Brain, Neurological Organization
Heavy Metal in Children's Tooth Enamel: Related to Autism and Disruptive Behaviors?
Peer reviewed Peer reviewed
Direct linkDirect link
Abdullah, Maryam M.; Ly, Agnes R.; Goldberg, Wendy A.; Clarke-Stewart, K. Alison; Dudgeon, John V.; Mull, Christopher G.; Chan, Tony J.; Kent, Erin E.; Mason, Andrew Z.; Ericson, Jonathon E. – Journal of Autism and Developmental Disorders, 2012
To examine possible links between neurotoxicant exposure and neuropsychological disorders and child behavior, relative concentrations of lead, mercury, and manganese were examined in prenatal and postnatal enamel regions of deciduous teeth from children with Autism Spectrum Disorders (ASDs), high levels of disruptive behavior (HDB), and typically…
Descriptors: Autism, Child Behavior, Metallurgy, Hazardous Materials
Brief Report: Biochemical Correlates of Clinical Impairment in High Functioning Autism and Asperger's Disorder
Peer reviewed Peer reviewed
Direct linkDirect link
Kleinhans, Natalia M.; Richards, Todd; Weaver, Kurt E.; Liang, Olivia; Dawson, Geraldine; Aylward, Elizabeth – Journal of Autism and Developmental Disorders, 2009
Amygdala dysfunction has been proposed as a critical contributor to social impairment in autism spectrum disorders (ASD). The current study investigated biochemical abnormalities in the amygdala in 20 high functioning adults with autistic disorder or Asperger's disorder and 19 typically developing adults matched on age and IQ. Magnetic resonance…
Descriptors: Autism, Asperger Syndrome, Brain, Adults