The aim of this study was to examine genetic variations underlying the early neurodevelopmental outcome of developmental disabilities (DDs). The study cohort consisted of 191 children with DDs. Diagnosis was assessed at baseline and at the index age (72-84 months). Exome sequencing was conducted and putative risk variants were identified.…

This paper charted the cognitive and behavioural profiles from toddlerhood to middle childhood in 48 children diagnosed with ASD at 24 months. The Mullen Scales of Early Learning (MSEL) was administered at 24- and 48-months and the Wechsler Abbreviated Scale of Intelligence (WASI) at school age. Autism severity was derived using The Autism…

Research on theory of mind (TOM) has provided a major contribution to the understanding of developmental disorders characterized by atypical social behaviour. Yet, there is still little consensus relative to TOM abilities in Williams syndrome (WS). This study used visual and verbal tasks to investigate attribution of intentions in individuals with…

This study examined Theory of Mind in Williams syndrome (WS) and in normal chronological age-matched and mental age-matched control groups, using a picture sequencing task. This task assesses understanding of pretence, intention and false belief, while controlling for social-script knowledge and physical cause-and-effect reasoning. The task was…

The study reports results of cognitive subtyping of 54 developmentally disabled children. Results tentatively suggest that such psychiatric manifestations as aloofness and maintenance of sameness may be relatively independent of cognitive skill patterns. (Author/CL)

Performance on a battery of cognitive measures was analyzed in terms of hand preference for 62 children (5-17 years old) with Pervasive Developmental Disorders including autism. There was a clear (though nonsignificant) trend on all tests for left-handers to have higher scores than right-handers. Mixed-hand preference Ss demonstrated the lowest…

A longitudinal study was conducted on 34 children with autism to evaluate the usefulness of the Treatment and Education of Autistic and related Communication Handicapped Children (TEACCH) program for Chinese pre-school children in Hong Kong. Eighteen children received full-time center-based TEACCH program training. The control group included 16…

This study sought to differentiate pervasive developmental disorder not otherwise specified (PDDNOS) from similar nonautistic disorders on the basis of a cognitive deficit, theory of mind (ToM), which is the ability to infer mental states in others, a deficit highly prevalent in autism, a disorder similar to PDDNOS. Results suggest that children…

The study of affect comprehension in 15 children with pervasive developmental disorders (ages 7-10) and normal children matched for mental age found that the disabled children were impaired on affect matching compared to the controls and were impaired on face and affect matching relative to their own performance on object matching. (Author/DB)

This study examined differences in sensory-motor, cognitive, and verbal impairment between 10 Japanese preschool children with Asperger Syndrome (AS) 10 children with high functioning autism (HFA) using the Japanese version of the Miller Assessment for Preschoolers. AS children surpassed HFA children in verbal skills but HFA children were better…

Hyperlexic children have superior word recognition skills accompanied by delayed development of cognitive and language abilities. Assessment of four hyperlexic children (ages 5-9) confirmed their superior abilities to retain sound/symbol associations. Written prompts were then effectively used to increase functional speech in one of the subjects.…