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DNA Methylation of the Oxytocin Receptor across Neurodevelopmental Disorders
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Siu, Michelle T.; Goodman, Sarah J.; Yellan, Isaac; Butcher, Darci T.; Jangjoo, Maryam; Grafodatskaya, Daria; Rajendram, Rageen; Lou, Youliang; Zhang, Rujun; Zhao, Chunhua; Nicolson, Rob; Georgiades, Stelios; Szatmari, Peter; Scherer, Stephen W.; Roberts, Wendy; Anagnostou, Evdokia; Weksberg, Rosanna – Journal of Autism and Developmental Disorders, 2021
Many neurodevelopmental disorders (NDDs) share common learning and behavioural impairments, as well as features such as dysregulation of the oxytocin hormone. Here, we examined DNA methylation (DNAm) in the 1st intron of the oxytocin receptor gene, "OXTR," in patients with autism spectrum (ASD), attention deficit and hyperactivity (ADHD)…
Descriptors: Genetics, Autism, Pervasive Developmental Disorders, Biochemistry
Presentation and Correlates of Hoarding Behaviors in Children with Autism Spectrum Disorders and Comorbid Anxiety or Obsessive-Compulsive Symptoms
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La Buissonnière-Ariza, Valérie; Wood, Jeffrey J.; Kendall, Philip C.; McBride, Nicole M.; Cepeda, Sandra L.; Small, Brent J.; Lewin, Adam B.; Kerns, Connor; Storch, Eric A. – Journal of Autism and Developmental Disorders, 2018
We investigated the presentation and correlates of hoarding behaviors in 204 children aged 7-13 with autism spectrum disorder (ASD) and comorbid anxiety or obsessive-compulsive disorder (OCD) symptoms. Approximately 34% of the sample presented at least moderate levels, and with 7% presenting severe to extreme levels of hoarding. Child gender…
Descriptors: Behavior Disorders, Child Behavior, Autism, Pervasive Developmental Disorders
Functional Characteristics of Disruptive Behavior in Developmentally Disabled Children with and without Autism
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Reese, R. Matthew; Richman, David M.; Belmont, John M.; Morse, Paige – Journal of Autism and Developmental Disorders, 2005
Expanding on Reese "et al." [2003], functional behavioral assessment interviews [O'Neill "et al.", 1997] concerning disruptive behavior were conducted with parents of 23 children with autism (6 females, 17 males, chronological ages [CA] 24-60 months) and 23 controls without autism pair-matched for CA, developmental age and sex. All children…
Descriptors: Young Children, Autism, Developmental Disabilities, Functional Behavioral Assessment
Adaptive and Maladaptive Behavior in Children with Smith-Magenis Syndrome
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Martin, Staci C.; Wolters, Pamela L.; Smith, Ann C. M. – Journal of Autism and Developmental Disorders, 2006
Children with Smith-Magenis Syndrome (SMS) exhibit deficits in adaptive behavior but systematic studies using objective measures are lacking. This descriptive study assessed adaptive functioning in 19 children with SMS using the Vineland Adaptive Behavior Scales (VABS). Maladaptive behavior was examined through parent questionnaires and the…
Descriptors: Behavior Disorders, Children, Daily Living Skills, Socialization