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Brief Report: Linguistic Mazes and Perseverations in School-Age Boys with Fragile X Syndrome and Autism Spectrum Disorder and Relationships with Maternal Maze Use
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Maltman, Nell; Friedman, Laura; Lorang, Emily; Sterling, Audra – Journal of Autism and Developmental Disorders, 2022
Autism spectrum disorder (ASD) and fragile X syndrome (FXS) are neurodevelopmental disorders with overlapping pragmatic language impairments. Prior work suggests pragmatic language differences may run in families. This study examined specific pragmatic difficulties (i.e., linguistic mazes and perseverations) in boys (9-18 years) with idiopathic…
Descriptors: Males, Genetic Disorders, Intellectual Disability, Autism
ASD Comorbidity in Fragile X Syndrome: Symptom Profile and Predictors of Symptom Severity in Adolescent and Young Adult Males
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Abbeduto, Leonard; Thurman, Angela John; McDuffie, Andrea; Klusek, Jessica; Feigles, Robyn Tempero; Ted Brown, W.; Harvey, Danielle J.; Adayev, Tatyana; LaFauci, Giuseppe; Dobkins, Carl; Roberts, Jane E. – Journal of Autism and Developmental Disorders, 2019
Many males with FXS meet criteria for ASD. This study was designed to (1) describe ASD symptoms in adolescent and young adult males with FXS (n = 44) and (2) evaluate the contributions to ASD severity of cognitive, language, and psychiatric factors, as well as FMRP (the protein deficient in FXS). A few ASD symptoms on the ADOS-2 were universal in…
Descriptors: Males, Genetic Disorders, Autism, Pervasive Developmental Disorders
Autism Symptomatology in Boys with Fragile X Syndrome: A Cross Sectional Developmental Trajectories Comparison with Nonsyndromic Autism Spectrum Disorder
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Thurman, Angela John; McDuffie, Andrea; Kover, Sara T.; Hagerman, Randi J.; Abbeduto, Leonard – Journal of Autism and Developmental Disorders, 2015
Although males with fragile X syndrome (FXS) are frequently described as demonstrating autism symptomatology, there is much debate regarding whether the behavioral symptoms representing the core domains of autism are the result of the same or different underlying neurological/psychological mechanisms. The present study used a cross-sectional…
Descriptors: Males, Genetic Disorders, Autism, Pervasive Developmental Disorders
Association of "GTF2i" in the Williams-Beuren Syndrome Critical Region with Autism Spectrum Disorders
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Malenfant, Patrick; Liu, Xudong; Hudson, Melissa L.; Qiao, Ying; Hrynchak, Monica; Riendeau, Noemie; Hildebrand, M. Jeannette; Cohen, Ira L.; Chudley, Albert E.; Forster-Gibson, Cynthia; Mickelson, Elizabeth C. R.; Rajcan-Separovic, Evica; Lewis, M. E. Suzanne; Holden, Jeanette J. A. – Journal of Autism and Developmental Disorders, 2012
Duplications of 7q11.23, deleted in Williams-Beuren Syndrome, have been implicated in autism spectrum disorders (ASDs). A 1.5 Mb duplication was identified in one girl with severe expressive language deficits and anxiety among 1,142 ASD individuals screened for this duplication. Family-based association studies of Tag-SNPs in three genes ("STX1A,"…
Descriptors: Autism, Interpersonal Relationship, Interaction, Etiology