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DNA Methylation of the Oxytocin Receptor across Neurodevelopmental Disorders
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Siu, Michelle T.; Goodman, Sarah J.; Yellan, Isaac; Butcher, Darci T.; Jangjoo, Maryam; Grafodatskaya, Daria; Rajendram, Rageen; Lou, Youliang; Zhang, Rujun; Zhao, Chunhua; Nicolson, Rob; Georgiades, Stelios; Szatmari, Peter; Scherer, Stephen W.; Roberts, Wendy; Anagnostou, Evdokia; Weksberg, Rosanna – Journal of Autism and Developmental Disorders, 2021
Many neurodevelopmental disorders (NDDs) share common learning and behavioural impairments, as well as features such as dysregulation of the oxytocin hormone. Here, we examined DNA methylation (DNAm) in the 1st intron of the oxytocin receptor gene, "OXTR," in patients with autism spectrum (ASD), attention deficit and hyperactivity (ADHD)…
Descriptors: Genetics, Autism, Pervasive Developmental Disorders, Biochemistry
Using Discrete Trial Training to Identify Specific Learning Impairments in Boys with Fragile X Syndrome
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Hall, Scott S.; Hustyi, Kristin M.; Hammond, Jennifer L.; Hirt, Melissa; Reiss, Allan L. – Journal of Autism and Developmental Disorders, 2014
We examined whether "discrete trial training" (DTT) could be used to identify learning impairments in mathematical reasoning in boys with fragile X syndrome (FXS). Boys with FXS, aged 10-23 years, and age and IQ-matched controls, were trained to match fractions to pie-charts and pie-charts to decimals either on a computer or with a…
Descriptors: Learning Disabilities, Mathematical Logic, Males, Genetic Disorders
Learning Curve Analyses in Neurodevelopmental Disorders: Are Children with Autism Spectrum Disorder Truly Visual Learners?
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Erdodi, Laszlo; Lajiness-O'Neill, Renee; Schmitt, Thomas A. – Journal of Autism and Developmental Disorders, 2013
Visual and auditory verbal learning using a selective reminding format was studied in a mixed clinical sample of children with autism spectrum disorder (ASD) (n = 42), attention-deficit hyperactivity disorder (n = 83), velocardiofacial syndrome (n = 17) and neurotypicals (n = 38) using the Test of Memory and Learning to (1) more thoroughly…
Descriptors: Attention Deficit Hyperactivity Disorder, Verbal Learning, Autism, Visual Learning
A Case of Partial Trisomy of Chromosome 8p Associated with Autism
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Papanikolaou, Katerina; Paliokosta, Elena; Gyftodimou, Jolanda; Kolaitis, Gerassimos; Vgenopoulou, Sofia; Sarri, Catherine; Tsiantis, John – Journal of Autism and Developmental Disorders, 2006
We report on a case of a 6-year-old female with partial trisomy 8p(21-23) associated with autism, mild dysmorphic features, and moderate learning disability. Although mental retardation is a common finding in patients with mosaic trisomy 8 or partial trisomy of various regions of chromosome 8, only two cases associated with autism have been…
Descriptors: Autism, Genetics, Young Children, Females
Is Autism Associated with Anomalous Dominance?
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Leboyer, Marion; And Others – Journal of Autism and Developmental Disorders, 1988
A theory of the development of anomalous dominance and its biological associations is explained and the literature is reviewed in an attempt to apply this theory to the study of autism. The review supported the increased incidence of left-handedness, learning disabilities, and immune disorders postulated by the theory. (Author/DB)
Descriptors: Autism, Brain Hemisphere Functions, Etiology, Genetics
Can Standard Measures Identify Subclinical Markers of Autism?
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Ozonoff, Sally; And Others – Journal of Autism and Developmental Disorders, 1993
This study provides support for a potential subclinical marker in the executive function domain of siblings (n=18, ages 8-18) of autistic individuals, compared to learning-disabled controls. No group differences in theory-of-mind abilities were found. The need to develop more sensitive measures is discussed. (Author/JDD)
Descriptors: Autism, Biological Influences, Cognitive Processes, Etiology