In this study, 11 males with autism and mental retardation were administered risperidone. Substantial clinical improvement was noted almost immediately; patients with aggression, self-injury, explosivity, and poor sleep hygiene were most improved. The modal dose for optimal response was 0.5 mg bid. Weight gain was a significant side effect.…

This article describes an individual (age 49) with mental retardation who experienced behavioral exacerbation associated with clonazepam prescribed at 2 mg/day to treat aggression, self-injurious behavior, property destruction, and screaming. When clonazepam was reduced and discontinued, these behaviors significantly decreased from 3.1% of…

A review of 41 studies on behavioral interventions for children with autism (ages 0-8) found aggression, tantrums, self-injury, and stereotypy were behaviors most targeted. Results also indicate interventions should be developed based on a thorough analysis of biological, antecedent, and consequence events that control them. Behavioral support…

Questionnaires completed by parents of 40 patients with Lesch-Nyhan disease provide information on developmental history, life course, management, medication, variability, and topography of self-injury. Analysis indicated that patients could not inhibit self-injury but could predict it and request restraints; self-injury was strongly related to…