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Direct linkLaidi, Charles; Boisgontier, Jennifer; de Pierrefeu, Amicie; Duchesnay, Edouard; Hotier, Sevan; d'Albis, Marc-Antoine; Delorme, Richard; Bolognani, Federico; Czech, Christian; Bouquet, Céline; Amestoy, Anouck; Petit, Julie; Holiga, Štefan; Dukart, Juergen; Gaman, Alexandru; Toledano, Elie; Ly-Le Moal, Myriam; Scheid, Isabelle; Leboyer, Marion; Houenou, Josselin – Journal of Autism and Developmental Disorders, 2019
Autism spectrum disorder (ASD) is a developmental disorder under-diagnosed in adults. To date, no consistent evidence of alterations in brain structure has been reported in adults with ASD and few studies were conducted at that age. We analyzed structural magnetic resonance imaging data from 167 high functioning adults with ASD and 195 controls.…
Descriptors: Adults, Autism, Pervasive Developmental Disorders, Brain
Stewart, Barbara A.; Klar, Amar J. S. – Journal of Autism and Developmental Disorders, 2013
Bronchoscopic evaluations revealed that some children have double branching of bronchi (designated "doublets") in the lower lungs airways, rather than normal, single branching. Retrospective analyses revealed only one commonality in them: all subjects with doublets also had autism or autism spectrum disorder (ASD). That is, 49 subjects exhibited…
Descriptors: Anatomy, Autism, At Risk Persons, Children
Lau, Yolanda C.; Hinkley, Leighton B. N.; Bukshpun, Polina; Strominger, Zoe A.; Wakahiro, Mari L. J.; Baron-Cohen, Simon; Allison, Carrie; Auyeung, Bonnie; Jeremy, Rita J.; Nagarajan, Srikantan S.; Sherr, Elliott H.; Marco, Elysa J. – Journal of Autism and Developmental Disorders, 2013
Autism spectrum disorders (ASD) have numerous etiologies, including structural brain malformations such as agenesis of the corpus callosum (AgCC). We sought to directly measure the occurrence of autism traits in a cohort of individuals with AgCC and to investigate the neural underpinnings of this association. We screened a large AgCC cohort (n =…
Descriptors: Autism, Brain, Neurological Impairments, Anatomy
Koolschijn, P. Cédric M. P.; Geurts, Hilde M. – Journal of Autism and Developmental Disorders, 2016
It is widely acknowledged that the brain anatomy of children and adolescents with autism spectrum disorder (ASD) shows a different developmental pattern then typical age-matched peers. There is however, a paucity of studies examining gray matter in mid and late adulthood in ASD. In this cross-sectional neuroimaging study, we, performed vertex-wise…
Descriptors: Adults, Older Adults, Pervasive Developmental Disorders, Case Studies
Tetreault, Nicole A.; Hakeem, Atiya Y.; Jiang, Sue; Williams, Brian A.; Allman, Elizabeth; Wold, Barbara J.; Allman, John M. – Journal of Autism and Developmental Disorders, 2012
We immunocytochemically identified microglia in fronto-insular (FI) and visual cortex (VC) in autopsy brains of well-phenotyped subjects with autism and matched controls, and stereologically quantified the microglial densities. Densities were determined blind to phenotype using an optical fractionator probe. In FI, individuals with autism had…
Descriptors: Comparative Analysis, Anatomy, Brain Hemisphere Functions, Brain
Kirkman, Nikki J.; Libbey, Jane E.; Sweeten, Thayne L.; Coon, Hilary H.; Miller, Judith N.; Stevenson, Edward K.; Lainhart, Janet E.; McMahon, William M.; Fujinami, Robert S. – Journal of Autism and Developmental Disorders, 2008
Controversy exists over the role of autoantibodies to central nervous system antigens in autism and Tourette Syndrome. We investigated plasma autoantibody titers to glial fibrillary acidic protein (GFAP) in children with classic onset (33) and regressive onset (26) autism, controls (25, healthy age- and gender-matched) and individuals with…
Descriptors: Neurological Impairments, Autism, Anatomy, Biochemistry
Libbey, Jane E.; Coon, Hilary H.; Kirkman, Nikki J.; Sweeten, Thayne L.; Miller, Judith N.; Stevenson, Edward K.; Lainhart, Janet E.; McMahon, William M.; Fujinami, Robert S. – Journal of Autism and Developmental Disorders, 2008
Autoantibodies to central nervous system antigens, such as myelin basic protein (MBP), may play a role in autism. We measured autoantibody titers to MBP in children with autism, both classic onset and regressive onset forms, controls (healthy age- and gender-matched) and individuals with Tourette syndrome via enzyme-linked immunosorbent assays. We…
Descriptors: Play, Autism, Anatomy, Pervasive Developmental Disorders
Thompson, Barbara L.; Stanwood, Gregg D. – Journal of Autism and Developmental Disorders, 2009
The formation and function of the mammalian cerebral cortex relies on the complex interplay of a variety of genetic and environmental factors through protracted periods of gestational and postnatal development. Biogenic amine systems are important neuromodulators, both in the adult nervous system, and during critical epochs of brain development.…
Descriptors: Symptoms (Individual Disorders), Pathology, Genetics, Anatomy
Hediger, Mary L.; England, Lucinda J.; Molloy, Cynthia A.; Yu, Kai F.; Manning-Courtney, Patricia; Mills, James L. – Journal of Autism and Developmental Disorders, 2008
Bone development, casein-free diet use, supplements, and medications were assessed for 75 boys with autism or autism spectrum disorder, ages 4-8 years. Second metacarpal bone cortical thickness (BCT), measured on hand-wrist radiographs, and % deviations in BCT from reference medians were derived. BCT increased with age, but % deviations evidenced…
Descriptors: Autism, Males, Physical Development, Human Body
Peer reviewedPiven, Joseph; Bailey, James; Ranson, Bonnie J.; Arndt, Stephan – Journal of Autism and Developmental Disorders, 1998
Neuropathological and animal studies have implicated the hippocampus as having a possible role in autism. This study applied magnetic resonance imaging to the hippocampus of 35 autistic and 36 control subjects. Detailed MRI did not reveal differences in the volume of the hippocampus in autistic individuals. (Author/DB)
Descriptors: Anatomy, Autism, Etiology, Neurology
Peer reviewedMinshew, Nancy J. – Journal of Autism and Developmental Disorders, 1996
This paper summarizes results of research on functional and structural abnormalities of the brain in autism. The current concept of causation is seen to involve multiple biologic levels. A consistent profile of brain function and dysfunction across methods has been found and specific neuropathologic findings have been found; but some research…
Descriptors: Anatomy, Autism, Etiology, Neurological Impairments
Peer reviewedBauman, Margaret L. – Journal of Autism and Developmental Disorders, 1996
This paper reviews neuroanatomic studies on syndromes classified as Pervasive Developmental Disorders. Findings in autism and Asperger's syndrome suggest that these two disorders may represent a continuum along a neurobiological spectrum with a common neuroanatomic substrate, while Rett syndrome appears to be clinically and anatomically distinct…
Descriptors: Anatomy, Neurological Impairments, Neurology, Pervasive Developmental Disorders
Cohen, David; Martel, Claire; Wilson, Anna; Dechambre, Nicole; Amy, Celine; Duverger, Ludovic; Guile, Jean-Marc; Pipiras, Eva; Benzacken, Brigitte; Cave, Helene; Cohen, Laurent; Heron, Delphine; Plaza, Monique – Journal of Autism and Developmental Disorders, 2007
Duplications of chromosome 15 may be one of the most common single genetic causes of autism spectrum disorders (ASD), aside from fragile X. Most of the cases are associated with maternally derived interstitial duplication involving 15q11-13. This case report describes a female proband with a maternally derived interstitial duplication of proximal…
Descriptors: Intelligence Quotient, Developmental Delays, Autism, Pervasive Developmental Disorders
Peer reviewedZielke, H. Ronald; And Others – Journal of Autism and Developmental Disorders, 1996
This paper describes the establishment and work of two brain and tissue banks, which collect brain and other tissues from newly deceased individuals with autism and make these tissues available to researchers. Issues in tissue collection are identified, including the importance of advance planning, religious concerns of families, and the need for…
Descriptors: Anatomy, Autism, Death, Etiology
Palmen, Saskia J. M. C.; Pol, Hilleke E. Hulshoff; Kemner, Chantal; Schnack, Hugo G.; Janssen, Joost; Kahn, Rene S.; van Engeland, Herman – Journal of Autism and Developmental Disorders, 2004
Background: Are brain volumes of individuals with Pervasive Developmental Disorder (PDD) still enlarged in adolescence and adulthood, and if so, is this enlargement confined to the gray and/or the white matter and is it global or more prominent in specific brain regions. Methods: Brain MRI scans were made of 21 adolescents with PDD and 21 closely…
Descriptors: Brain, Pervasive Developmental Disorders, Adolescents, Patients
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