This paper reviews the literature exploring gender differences associated with the clinical presentation of autism spectrum disorders (ASD). The potentially mediating effect of comorbid psychopathology, biological and neurodevelopmental implications on these gender differences is also discussed. A vastly heterogeneous condition, while females on…

Research on risk factors for schizophrenia is reviewed with emphasis on children of schizophrenic parents. Four areas of biobehavioral functioning that have been examined in high-risk research are discussed. Three of these are considered compatible with hypothesis neurointegrative defect underlying schizophrenic-proneness. (Author/CL)

The article describes a study being conducted to explore the hypothesis that genetic and/or congenital factors are etiologically significant in certain persons with the syndrome of autism. Preliminary data suggest a larger than expected number of families with multiple incidence of autism. (Author/DB)

The fundamental preclinical and clinical studies of serotonin, dopamine, and norepinephrine metabolism related to infantile autism are reviewed, and new studies are suggested, as examples of the productive strategies that will illuminate features of the autistic syndrome in the next decade. (Author)

A review of current literature suggests that many cases of autism may well have both environmental and genetic etiologies and that more than one genetic locus is likely. Some evidence suggests that some genetic abnormality of language or sociability is inherited which then interacts with other factors to produce autism. (DB)

A study of 202 patients with autism found the incidence of a dodecamer duplication in the HOPA gene was not significantly different between patients and controls. Three female patients inherited the duplication from nonautistic fathers. Also, there was no systematic skewing of X inactivation in female patients with the duplication. (Contains…

A study of the development of epilepsy in adolescents with autism investigated the brain dysfunctions in 158 patients (ages 15-28) with autism through the examination of paroxysmal electroencephalographic abnormalities. Results indicated that 47.5% of the individuals with autism had such abnormalities in the frontal region. (CR)

Birth order and maternal ages at time of birth were compared for 113 autistic children (3 to 12 years old) and the Iowa general population. An excess of mothers aged 35 or older was observed in the autistic group. A deviation from average in birth order was observed in autistics. (Author/SEW)

This paper presents two case studies of children who developed herpes virus infection in the intrauterine or early postnatal period and presented with features of autism around two years of age. Other research suggesting a link between herpes and autism is reviewed. (DB)

This study provides support for a potential subclinical marker in the executive function domain of siblings (n=18, ages 8-18) of autistic individuals, compared to learning-disabled controls. No group differences in theory-of-mind abilities were found. The need to develop more sensitive measures is discussed. (Author/JDD)

This article reviews studies linking autistic disorder with various immune factors. It concludes that although various immune system abnormalities have been reported in children with autism, previous studies are largely association based and it remains difficult to draw conclusions regarding the role of immune factors in the etiopathogenesis of…

This paper discusses language and communication deficits observed in autism within the framework of the "theory of mind" hypothesis, which posits that autistic individuals have profound difficulty interpreting a person's actions within a mentalistic framework. Placing language and communicative deficits within a theory of mind framework…

This paper explores the neural systems underlying social behaviors as they pertain to autism. It discusses major channels for transmission of social-emotional information, neural pathways subserving social behaviors, and social cognition in autism. A hypothesis of autism based on deviant development of the widely distributed neural system…

Social escape behavior is a common behavioral feature of individuals with fragile X syndrome (fraX). In this observational study, we examined the effect of antecedent social and performance demands on problem behaviors in four conditions: face-to-face interview, silent reading, oral reading and a singing task. Results showed that problem behaviors…

Experts (n=31) in the field of autism indicated past progress in the field, were optimistic in continued progress in identifying the biological underpinnings of autism, stressed the role of research, and identified and clarified fundamental concerns and issues of the field (e.g., community integration, outcome and program evaluation, and family…