Among the approaches to the study of career interests, the person-centered profile approach (i.e., studying the career interest profiles of individuals), rather than the traditional construct-centered approach, has gained more attention in recent years. In our research, we intend to advance our understanding of career interests with the person-centered profile approach and address some important conceptual and methodological issues raised by previous studies. Based on the cultural context of Hong Kong after the 1997 handover, we hypothesized four general career interest profiles for Hong Kong high school graduates. Using a sample of senior secondary school graduates who were not admitted into undergraduate programs and a cohort sample of first-year university students, we found support for this hypothesis. This classification was validated by its relationships with career decisiveness, parents' open communication style, and life satisfaction. Our research provides guidelines to test the validity of the proposed forms of career interest profiles.