The ability to extract structural information from a drawing of a molecule is key to being successful in organic chemistry. One source of difficulty for novices in interpreting structures is that hydrogens bound to carbon are represented implicitly in the often-used line-angle structures. Other representations that explicitly show hydrogens, such…

A Fourier transform infrared (FTIR) experiment appropriate for an upper-level undergraduate laboratory such as chemical instrumentation is described. Students collect FTIR spectra of four protio-solvents and their deuterated analogues. In addition to qualitatively observing C-H and O-H peaks shift to lower energy upon deuteration, students apply a…

As part of COVID-19 preparedness, a student-developed, Android-based app was used as a pre-laboratory learning aid for a molecular modeling laboratory in a first-year general chemistry course. A worksheet activity with trigger codes and questions related to spatial features of transition metal complexes was designed. Using the Transition Metal…

Structures of 10 proteins from the Protein Data Bank were 3D printed as part of an undergraduate biochemistry teaching laboratory. All structures were successfully printed in either a space filling surface representation or a cartoon representation that traces the Ca carbon atoms of each amino acid residue. All structures were printed using…

Visualization can be a motivating way to teach students about molecules. Nowadays, the available experimental data and accurate computational results allow students to build realistic and accurate molecular models. These models include the representation of complex systems such as proteins, membranes, or nanotubes. However, the visualization of…

We present an accessible implementation of augmented reality projections for the depiction of complex structures and motifs, including atomic orbitals and elemental allotropes. The utilization of a free, cross-platform-compatible, online database of these structures provides the access route for closer examination, either via augmented reality or…

Decades of research have demonstrated the correlation of spatial abilities to chemistry achievement and career selection. Nonetheless, reviews have highlighted the need and scarcity of explicit spatial instruction to promote spatial skills. Therefore, the goal of this literature review is to summarize what has been done during the past decade in…

In this activity, students manipulate three-dimensional molecular models of the Ala-Ala-Ala tripeptide, where Ala is alanine. They rotate bonds to show that the pairs of dihedral angles phi = 0 degrees, psi = 180 degrees, and phi = 0 degrees, psi = 0 degrees lead to unfavorable interactions among the main chain atoms of the tripeptide. This…

A 3D model visualization and basic molecular modeling laboratory suitable for first-year undergraduates studying introductory medicinal chemistry is presented. The 2 h practical is embedded within a series of lectures on drug design, target-drug interactions, enzymes, receptors, nucleic acids, and basic pharmacokinetics. Serving as a teaching aid…

An upper-division undergraduate laboratory experiment is described that explores the structure/function relationship of protein domains, namely leucine zippers, through a molecular graphics computer program and physical models fabricated by 3D printing. By generating solvent accessible surfaces and color-coding hydrophobic, basic, and acidic amino…

Three physical model systems have been developed to help students deconstruct the visualization needed when learning symmetry and group theory. The systems provide students with physical and visual frames of reference to facilitate the complex visualization involved in symmetry concepts. The permanent reflection plane demonstration presents an…

Chemists and scientists use spatial abilities as part of the way they understand and communicate their subject areas. A review of the foundational research literature in spatial ability and its connections to chemistry as a field and chemical education research allows for the formulation of implications for teaching in chemistry. (Contains 7…

A system for construction of simple poster-board models is described. The models dynamically demonstrate the symmetry operations of proper rotation, improper rotation, reflection, and inversion for the chemically important point groups D[subscript 3h], D[subscript 4h], D[subscript 5h], D[subscript 6h], T[subscript d], and O[subscript h]. The…

Twelve pentagons are sufficient and necessary to form a fullerene cage. According to this structural feature of fullerenes, we propose a simple and efficient method for the construction of I[subscript h] symmetrical fullerenes from pentagons. This method does not require complicated mathematical knowledge; yet it provides an excellent paradigm for…

This study measures changes in teachers' attitudes, content knowledge, and spatial ability following a two-year visualization workshop experience. The workshop involved intensive, half-day sessions over three weeks for two consecutive summers, in which the participants worked with three-dimensional models and computer-generated images. No changes…