This study investigated whether participation in a 1-semester science course for college students who are not majoring in the natural sciences could increase their scientific literacy, confidence in doing science and improve their perception of science and scientists. The study was conducted at a small, 4-year, liberal arts institution in Portland Oregon. Participants included a majority of female students, both lower and upper classmen and students majoring in either Arts/Humanities or Social Sciences. Female students, lowerclassmen and students majoring in Arts or Humanities had significant increases in scientific literacy and confidence to do science, while upperclassmen and students majoring in Social Sciences had significant increases for scientific literacy, but not for confidence in doing science. This study is an example of the benefits of science courses for non-science majors and suggests different approaches may be needed to reach different student populations.