The number of international students in US higher education has grown significantly in the past decade; in 2018-19, more than 1 million foreign students were studying in the US (Institute of International Education, 2019). Many incoming college students, both domestic and international, experience psychological difficulties that may result from transitions such as leaving their hometowns, living in new environments, and encountering strangers (Mayhew et al., 2016; Pedersen et al., 2016). Moreover, international students face additional challenges such as cultural differences and language barriers (Cho & Yu, 2015), so administrators and faculty members may need to pay particular attention to the mental health of these students. In this article, the authors analyzed the relationship between first-year international students' interpersonal interactions and changes in psychological well-being (PWB) at US colleges and universities. The findings suggest that interactions with peers may be crucial for international students' PWB during the first year of college; thus, US colleges and universities should foster international students' opportunities for meaningful interactions, which can be complicated by language, cultural differences, and other challenges. Moreover, promoting student affairs and student services to international students may be effective for bolstering PWB, since broad attention to student life is considerably more prevalent within the US, and international students may not be familiar with these services. Providing orientation sessions and workshops that are tailored exclusively toward international students, who may not be aware of on-campus opportunities and services, would also be helpful. Additionally, institutions should consider training for faculty and staff on how to engage effectively with international students to improve the nature of these interactions as well as the outcomes that may result from them.