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Self-Injurious Behaviour in Intellectual Disability Syndromes: Evidence for Aberrant Pain Signalling as a Contributing Factor
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Peebles, K. A.; Price, T. J. – Journal of Intellectual Disability Research, 2012
Background: In most individuals, injury results in activation of peripheral nociceptors (pain-sensing neurons of the peripheral nervous system) and amplification of central nervous system (CNS) pain pathways that serve as a disincentive to continue harmful behaviour; however, this may not be the case in some developmental disorders that cause…
Descriptors: Pain, Mental Retardation, Self Destructive Behavior, Neurology