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Direct linkFahim, C.; Yoon, U.; Nashaat, N. H.; Khalil, A. K.; El-Belbesy, M.; Mancini-Marie, A.; Evans, A. C.; Meguid, N. – Journal of Intellectual Disability Research, 2012
Background: Genetically Williams syndrome (WS) promises to provide essential insight into the pathophysiology of cortical development because its ~28 deleted genes are crucial for cortical neuronal migration and maturation. Phenotypically, WS is one of the most puzzling childhood neurodevelopmental disorders affecting most intellectual…
Descriptors: Attention Deficit Disorders, Intelligence Quotient, Genetics, Scientific Research
Muehlmann, A. M.; Lewis, M. H. – Journal of Intellectual Disability Research, 2012
Background: Self-injurious behaviour (SIB) is a devastating problem observed in individuals with various neurodevelopmental disorders, including specific genetic syndromes as well as idiopathic intellectual and developmental disability. Although an increased prevalence of SIB has been documented in specific genetic mutations, little is known about…
Descriptors: Behavior Problems, Anxiety Disorders, Animals, Mental Retardation
Whittington, J.; Holland, A.; Webb, T.; Butler, J.; Clarke, D.; Boer, H. – Journal of Intellectual Disability Research, 2004
Prader-Willi syndrome (PWS) is characterized by extreme floppiness at birth, impaired sexual development, short stature, severe over-eating, characteristic physical features and learning disabilities (LD). Impaired social cognition, literal mindedness and cognitive inflexibility are also present. The syndrome has two main genetic subtypes that…
Descriptors: Cognitive Ability, Verbal Ability, Social Cognition, Sexuality
