Five experiments used ERPs and eye tracking to determine the interplay of word-level and discourse-level information during sentence processing. Subjects read sentences that were locally congruent but whose congruence with discourse context was manipulated. Furthermore, critical words in the local sentence were preceded by a prime word that was associated or not. Violations of discourse congruence had early and lingering effects on ERP and eye-tracking measures. This indicates that discourse representations have a rapid effect on lexical semantic processing even in locally congruous texts. In contrast, effects of association were more malleable: Very early effects of associative priming were only robust when the discourse context was absent or not cohesive. Together these results suggest that the global discourse model quickly influences lexical processing in sentences, and that spreading activation from associative priming does not contribute to natural reading in discourse contexts.