This study investigates the latent structure of individual differences in vocational, leisure, and family interests. The participants consisted of 302 French adults who rated their like or dislike for activities based on Holland's RIASEC typology and presented in three life domains: work, family and leisure. The multitrait-multimethod model proposed by Eid [Eid, M. (2000). "A multitrait-multimethod model with minimal assumptions." "Psychometrika" 65, 241-261.] was used with the vocational interests as standard comparison, and was applied separately on each of the 6 RIASEC types. Results indicated that interests strongly intercorrelated whatever their vocational vs. leisure or family contextualization. However, since these correlations were controlled for measurement error, the results also suggested that the effects of these contextualizations of the activities could not be ignored because they accounted for a non negligible part of the variance for several activities. Theoretical and practical implications are discussed and directions for future research are presented.