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Amorim, Felippe E.; Chapot, Renata L.; Chapot, Renata L.; Lee, Jonathan L. C.; Amaral, Olavo B. – Learning & Memory, 2021
Remembering is not a static process: When retrieved, a memory can be destabilized and become prone to modifications. This phenomenon has been demonstrated in a number of brain regions, but the neuronal mechanisms that rule memory destabilization and its boundary conditions remain elusive. Using two distinct computational models that combine…
Descriptors: Memory, Brain Hemisphere Functions, Biochemistry, Behavior Patterns
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Keiser, Ashley A.; Wood, Marcelo A. – Learning & Memory, 2019
The epigenome serves as a signal integration platform that encodes information from experience and environment that adds tremendous complexity to the regulation of transcription required for memory, beyond the directions encoded in the genome. To date, our understanding of how epigenetic mechanisms integrate information to regulate gene expression…
Descriptors: Memory, Gender Differences, Molecular Structure, Genetics
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Hegde, Ashok N.; Smith, Spencer G. – Learning & Memory, 2019
Formation of long-term synaptic plasticity that underlies long-term memory requires new protein synthesis. Years of research has elucidated some of the transcriptional and translational mechanisms that contribute to the production of new proteins. Early research on transcription focused on the transcription factor cAMP-responsive element binding…
Descriptors: Memory, Brain Hemisphere Functions, Biochemistry, Molecular Structure
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Marchal, Paul; Villar, Maria Eugenia; Geng, Haiyang; Arrufat, Patrick; Combe, Maud; Viola, HaydĂ©e; Massou, Isabelle; Giurfa, Martin – Learning & Memory, 2019
Honeybees are a standard model for the study of appetitive learning and memory. Yet, fewer attempts have been performed to characterize aversive learning and memory in this insect and uncover its molecular underpinnings. Here, we took advantage of the positive phototactic behavior of bees kept away from the hive in a dark environment and…
Descriptors: Inhibition, Learning Processes, Memory, Molecular Structure
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Jia, Margaret; Travaglia, Alessio; Pollonini, Gabriella; Fedele, Giuseppe; Alberini, Cristina M. – Learning & Memory, 2018
The medial prefrontal cortex (mPFC) plays a critical role in complex brain functions including decision-making, integration of emotional, and cognitive aspects in memory processing and memory consolidation. Because relatively little is known about the molecular mechanisms underlying its development, we quantified rat mPFC basal expression levels…
Descriptors: Animals, Brain Hemisphere Functions, Biochemistry, Cognitive Processes
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Ahmadiantehrani, Somayeh; Gores, Elisa O.; London, Sarah E. – Learning & Memory, 2018
Nonassociative learning is considered simple because it depends on presentation of a single stimulus, but it likely reflects complex molecular signaling. To advance understanding of the molecular mechanisms of one form of nonassociative learning, habituation, for ethologically relevant signals we examined song recognition learning in adult zebra…
Descriptors: Habituation, Associative Learning, Correlation, Singing
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Lyons, Lisa C.; Gardner, Jacob S.; Gandour, Catherine E.; Krishnan, Harini C. – Learning & Memory, 2017
We investigated the in vivo role of protein degradation during intermediate (ITM) and long-term memory (LTM) in "Aplysia" using an operant learning paradigm. The proteasome inhibitor MG-132 inhibited the induction and molecular consolidation of LTM with no effect on ITM. Remarkably, maintenance of steady-state protein levels through…
Descriptors: Memory, Biochemistry, Brain Hemisphere Functions, Role
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Ardiel, Evan L.; Giles, Andrew C.; Yu, Alex J.; Lindsay, Theodore H.; Lockery, Shawn R.; Rankin, Catharine H. – Learning & Memory, 2016
Habituation is a highly conserved phenomenon that remains poorly understood at the molecular level. Invertebrate model systems, like "Caenorhabditis elegans," can be a powerful tool for investigating this fundamental process. Here we established a high-throughput learning assay that used real-time computer vision software for behavioral…
Descriptors: Habituation, Computer Software, Stimulation, Behavior Patterns
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Barrett, Ruth M.; Wood, Marcelo A. – Learning & Memory, 2008
One of the alluring aspects of examining chromatin modifications in the role of modulating transcription required for long-term memory processes is that these modifications may provide transient and potentially stable epigenetic marks in the service of activating and/or maintaining transcriptional processes. These, in turn, may ultimately…
Descriptors: Drug Addiction, Genetics, Long Term Memory, Depression (Psychology)
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Oliveira, Ana M. M.; Wood, Marcelo A.; McDonough, Conor B.; Abel, Ted – Learning & Memory, 2007
The formation of many forms of long-term memory requires several molecular mechanisms including regulation of gene expression. The mechanisms directing transcription require not only activation of individual transcription factors but also recruitment of transcriptional coactivators. CBP and p300 are transcriptional coactivators that interact with…
Descriptors: Recognition (Psychology), Biochemistry, Long Term Memory, Animals
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Brown, Travis E.; Forquer, Melissa R.; Cocking, Davelle L.; Jansen, Heiko T.; Harding, Joseph W.; Sorg, Barbara A. – Learning & Memory, 2007
Persistent drug seeking/taking behavior involves the consolidation of memory. With each drug use, the memory may be reactivated and reconsolidated to maintain the original memory. During reactivation, the memory may become labile and susceptible to disruption; thus, molecules involved in plasticity should influence acquisition and/or…
Descriptors: Memory, Cocaine, Molecular Structure, Biochemistry