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Sekeres, Melanie J.; Moscovitch, Morris; Grady, Cheryl L.; Sullens, D. Gregory; Winocur, Gordon – Learning & Memory, 2020
Conditioned fear memories that are context-specific shortly after conditioning generalize over time. We exposed rats to a context reminder 30 d after conditioning, which served to reinstate context-specificity, and investigated how this reminder alters retrieval-induced activity in the hippocampus and anterior cingulate cortex (aCC) relative to a…
Descriptors: Memory, Animals, Brain Hemisphere Functions, Conditioning
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Marchal, Paul; Villar, Maria Eugenia; Geng, Haiyang; Arrufat, Patrick; Combe, Maud; Viola, HaydĂ©e; Massou, Isabelle; Giurfa, Martin – Learning & Memory, 2019
Honeybees are a standard model for the study of appetitive learning and memory. Yet, fewer attempts have been performed to characterize aversive learning and memory in this insect and uncover its molecular underpinnings. Here, we took advantage of the positive phototactic behavior of bees kept away from the hive in a dark environment and…
Descriptors: Inhibition, Learning Processes, Memory, Molecular Structure
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Pevzner, Aleksandr; Guzowski, John F. – Learning & Memory, 2015
No studies to date have examined whether immediate-early gene (IEG) activation is driven by context memory recall. To address this question, we utilized the context preexposure facilitation effect (CPFE) paradigm. In CPFE, animals acquire contextual fear conditioning through hippocampus-dependent rapid retrieval of a previously formed contextual…
Descriptors: Genetics, Correlation, Recall (Psychology), Context Effect
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Vieira, Philip A.; Lovelace, Jonathan W.; Corches, Alex; Rashid, Asim J.; Josselyn, Sheena A.; Korzus, Edward – Learning & Memory, 2014
The neural mechanisms underlying the attainment of fear memory accuracy for appropriate discriminative responses to aversive and nonaversive stimuli are unclear. Considerable evidence indicates that coactivator of transcription and histone acetyltransferase cAMP response element binding protein (CREB) binding protein (CBP) is critically required…
Descriptors: Neurological Organization, Neurology, Fear, Memory
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Lapidus, Kyle A. B.; Nwokafor, Chiso; Scott, Daniel; Baroni, Timothy E.; Tenenbaum, Scott A.; Hiroi, Noboru; Singer, Robert H.; Czaplinski, Kevin – Learning & Memory, 2012
To directly address whether regulating mRNA localization can influence animal behavior, we created transgenic mice that conditionally express Zipcode Binding Protein 1 (ZBP1) in a subset of neurons in the brain. ZBP1 is an RNA-binding protein that regulates the localization, as well as translation and stability of target mRNAs in the cytoplasm. We…
Descriptors: Animals, Cocaine, Conditioning, Animal Behavior
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Isiegas, Carolina; Stein, Joel; Hellman, Kevin; Hannenhalli, Sridhar; Abel, Ted; Keeley, Michael B.; Wood, Marcelo A. – Learning & Memory, 2006
Classical fear conditioning requires the recognition of conditioned stimuli (CS) and the association of the CS with an aversive stimulus. We used Affymetrix oligonucleotide microarrays to characterize changes in gene expression compared to naive mice in both the amygdala and the hippocampus 30 min after classical fear conditioning and 30 min after…
Descriptors: Fear, Genetics, Stimuli, Animals
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Frey, Julietta U.; Korz, Volker; Uzakov, Shukhrat – Learning & Memory, 2005
Hippocampal long-term potentiation (LTP) can be dissociated in early-LTP lasting 4-5 h and late-LTP with a duration of more than 8 h, the latter of which requires protein synthesis and heterosynaptic activity during its induction. Previous studies in vivo have shown that early-LTP in the dentate gyrus can protein synthesis-dependently be…
Descriptors: Foreign Countries, Long Term Memory, Comparative Analysis, Brain